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Lgals3 Gene Detail
Summary
  • Symbol
    Lgals3
  • Name
    lectin, galactose binding, soluble 3
  • Synonyms
    gal3, galectin-3, L-34, Mac-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96778
    NCBI Gene: 16854
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:47611317-47623624 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 24.60 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    435 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96778
 protein coding gene Chr14:47605208-47623624 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021221
 protein coding gene Chr14:41114507-41133610 (+)
A/J MGP_AJ_G0021169
 protein coding gene Chr14:39870552-39890547 (+)
AKR/J MGP_AKRJ_G0021147
 protein coding gene Chr14:41423312-41442516 (+)
BALB/cJ MGP_BALBcJ_G0021172
 protein coding gene Chr14:39928090-39949549 (+)
C3H/HeJ MGP_C3HHeJ_G0020956
 protein coding gene Chr14:41206072-41228482 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021607
 protein coding gene Chr14:42855923-42874050 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019166
 protein coding gene Chr14:39226242-39244877 (+)
CAST/EiJ MGP_CASTEiJ_G0020481
 protein coding gene Chr14:38328386-38347239 (+)
CBA/J MGP_CBAJ_G0020922
 protein coding gene Chr14:44228215-44249031 (+)
DBA/2J MGP_DBA2J_G0021045
 protein coding gene Chr14:39761828-39780904 (+)
FVB/NJ MGP_FVBNJ_G0021030
 protein coding gene Chr14:39506088-39524463 (+)
LP/J MGP_LPJ_G0021115
 protein coding gene Chr14:41390258-41409665 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021055
 protein coding gene Chr14:43582632-43604212 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021640
 protein coding gene Chr14:40964049-40983436 (+)
PWK/PhJ MGP_PWKPhJ_G0020230
 protein coding gene Chr14:36638014-36659715 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020054
 protein coding gene Chr14:37086628-37107117 (+)
WSB/EiJ MGP_WSBEiJ_G0020537
 protein coding gene Chr14:41064787-41082510 (+)



Homology
more
  • Human Ortholog
    LGALS3, galectin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LGALS3, galectin 3
  • Synonyms
    CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2
  • Links
    NCBI Gene ID: 3958
    neXtProt AC: NX_P17931
    UniProt: P17931

  • Chr Location
    14q22.3; chr14:55124110-55145430 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lgals3 mouse models; 1 with human LGALS3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    80 phenotypes from 3 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    184 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show susceptibility to S. pneumoniae infection, resistance to renal fibrosis, defects in chondrocyte differentiation, and impaired macrophage activation. Homozygotes for another null allele show altered peritoneal inflammation, and susceptibility to T. gondii infection. Homozygosity for a glycan-binding deficient mutation leads to increased vertebral bone density in aged female mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    77
  • cDNA Data
    301
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16854 NCBI Gene Model | MGI Sequence Detail 12308 C57BL/6J ±  kb
    transcript NM_001145953 RefSeq | MGI Sequence Detail 1406 C57BL/6  
    polypeptide P16110 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 311
      Genomic 5
      cDNA 301
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11797
    References
    more
    • Summaries
      All 318
      Developmental Gene Expression 32
      Diseases 2
      Gene Ontology 18
      Phenotypes 184
    • Earliest
      J:17163 Jia S, et al., Carbohydrate binding protein 35. Complementary DNA sequence reveals homology with proteins of the heterogeneous nuclear RNP. J Biol Chem. 1988 May 5;263(13):6009-11
    • Latest
      J:354299 Kim KS, et al., TIM-3 on myeloid cells promotes pulmonary inflammation through increased production of galectin-3. Commun Biol. 2024 Sep 5;7(1):1090
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory