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Lifr Gene Detail
Summary
  • Symbol
    Lifr
  • Name
    LIF receptor alpha
  • Synonyms
    A230075M04Rik, soluble differentiation-stimulating factor receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96788
    NCBI Gene: 16880
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:7120095-7226970 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 3.46 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3184 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96788
 protein coding gene Chr15:7120091-7226970 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021700
 protein coding gene Chr15:4139991-4211455 (+)
A/J MGP_AJ_G0021661
 protein coding gene Chr15:4049495-4117650 (+)
AKR/J MGP_AKRJ_G0021639
 protein coding gene Chr15:4065109-4140819 (+)
BALB/cJ MGP_BALBcJ_G0021668
 protein coding gene Chr15:3958212-4027252 (+)
C3H/HeJ MGP_C3HHeJ_G0021444
 protein coding gene Chr15:4102334-4172213 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022107
 protein coding gene Chr15:4301837-4373395 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019644
 protein coding gene Chr15:3669219-3738707 (+)
CAST/EiJ MGP_CASTEiJ_G0020960
 protein coding gene Chr15:4081618-4151564 (+)
CBA/J MGP_CBAJ_G0021413
 protein coding gene Chr15:4376534-4449887 (+)
DBA/2J MGP_DBA2J_G0021537
 protein coding gene Chr15:3969739-4037810 (+)
FVB/NJ MGP_FVBNJ_G0021515
 protein coding gene Chr15:3898417-3966912 (+)
LP/J MGP_LPJ_G0021605
 protein coding gene Chr15:4066727-4134486 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021540
 protein coding gene Chr15:4569977-4639132 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022130
 protein coding gene Chr15:4100560-4171987 (+)
PWK/PhJ MGP_PWKPhJ_G0020703
 protein coding gene Chr15:3986835-4057816 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020541
 protein coding gene Chr15:3998691-4069154 (+)
WSB/EiJ MGP_WSBEiJ_G0021016
 protein coding gene Chr15:4039477-4108293 (+)



Homology
more
  • Human Ortholog
    LIFR, LIF receptor subunit alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIFR, LIF receptor subunit alpha
  • Synonyms
    CD118, LIF-R, SJS2, STWS, SWS
  • Links
    NCBI Gene ID: 3977
    neXtProt AC: NX_P42702
    UniProt: P42702

  • Chr Location
    5p13.1; chr5:38474668-38608403 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lifr mouse models; 1 with human LIFR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 4 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die as neonates with reduced numbers of facial and spinal motor neurons, neurons of the nucleus ambiguus, and astrocytes. Mutants also show impaired placentation, severe osteopenia, and low hepatic glycogen stores.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1134
  • Tissues
    122
  • cDNA Data
    87
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054263 Ensembl Gene Model | MGI Sequence Detail 106876 C57BL/6J ±  kb
    transcript ENSMUST00000067190 Ensembl | MGI Sequence Detail 4143 Not Applicable  
    polypeptide ENSMUSP00000064551 Ensembl | MGI Sequence Detail 1092 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000001876 leukemia inhibitory factor receptor
      (term hierarchy)
    • PDB
      2Q7N
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR040817 Leukemia inhibitory factor receptor, D2 domain
      IPR048497 Leukemia inhibitory factor receptor-like, Ig-like domain
      IPR040901 Leukemia inhibitory factor receptor, N-terminal
      IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
      IPR050379 Type I Cytokine Receptor
    • GlyGen
      P42703 16 sites, 11 N-linked glycans (8 sites)
    Molecular
    Reagents
    less
    • All nucleic 109
      Genomic 12
      cDNA 88
      Primer pair 5
      Other 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11808, MGI:2146188, MGI:2442497
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 35
      Diseases 1
      Gene Ontology 8
      Phenotypes 39
    • Earliest
      J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
    • Latest
      J:346035 Yang X, et al., Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice. Nat Commun. 2024 Jan 20;15(1):627
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory