Lmnb2 MGI Mouse Gene Detail - MGI:96796

Symbol

Lmnb2
Name

lamin B2
Synonyms

lamin B3

Feature Type

protein coding gene
IDs

MGI:96796
NCBI Gene: 16907
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:80737197-80754079 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C
Mapping Data

5 experiments

SNPs within 2kb

446 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96796	protein coding gene	Chr10:80737037-80754079 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017528	protein coding gene	Chr10:81572061-81591077 (-)
A/J	MGP_AJ_G0017506	protein coding gene	Chr10:78694531-78711349 (-)
AKR/J	MGP_AKRJ_G0017467	protein coding gene	Chr10:80854182-80872846 (-)
BALB/cJ	MGP_BALBcJ_G0017468	protein coding gene	Chr10:78909867-78927345 (-)
C3H/HeJ	MGP_C3HHeJ_G0017291	protein coding gene	Chr10:80943501-80960384 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017922	protein coding gene	Chr10:84369514-84387266 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015611	protein coding gene	Chr10:74904876-74921524 (-)
CAST/EiJ	MGP_CASTEiJ_G0016858	protein coding gene	Chr10:81171855-81191806 (-)
CBA/J	MGP_CBAJ_G0017263	protein coding gene	Chr10:87643164-87663051 (-)
DBA/2J	MGP_DBA2J_G0017369	protein coding gene	Chr10:77892101-77908898 (-)
FVB/NJ	MGP_FVBNJ_G0017363	protein coding gene	Chr10:77125387-77143848 (-)
LP/J	MGP_LPJ_G0017440	protein coding gene	Chr10:82024160-82042183 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017389	protein coding gene	Chr10:89549350-89565942 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017963	protein coding gene	Chr10:80844813-80862495 (-)
PWK/PhJ	MGP_PWKPhJ_G0016639	protein coding gene	Chr10:77786746-77805069 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016429	protein coding gene	Chr10:79795611-79812172 (-)
WSB/EiJ	MGP_WSBEiJ_G0016918	protein coding gene	Chr10:80884260-80902122 (-)

Human Ortholog

LMNB2, lamin B2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LMNB2, lamin B2
Synonyms

EPM9, LAMB2, LMN2, MCPH27
Links

HGNC:6638

NCBI Gene ID: 84823

neXtProt AC: NX_Q03252

UniProt: Q03252
Chr Location

19p13.3

MGI Vertebrate Homology

Lmnb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LMNB2
Gene Tree

Lmnb2

Diseases

3 with human LMNB2 associations

				Human Disease	Mouse Models
				partial lipodystrophy IDs partial lipodystrophy DOID:0080299
				primary autosomal recessive microcephaly IDs primary autosomal recessive microcephaly DOID:0070296 OMIM:PS251200 ORDO:2512
				progressive myoclonus epilepsy 9 IDs progressive myoclonus epilepsy 9 DOID:0111450 OMIM:616540 ORDO:457265

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 5 alleles in 4 genetic backgrounds
18 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Targeted

11
Genomic Mutations

1 involving Lmnb2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit neonatal death with abnormal brain development.

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All GO Annotations

17
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

9
cDNA Data

61
Literature Summary

21

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LMNB2

Xenbase lmnb2

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All Sequences

47
RefSeq

4
UniProt

3
CCDS

CCDS24037.2, CCDS83733.1

Ensembl

ENSMUSG00000062075 (Evidence)
NCBI Gene

16907

			Length	Strain/Species	Flank
genomic	16907	NCBI Gene Model \| MGI Sequence Detail	16883	C57BL/6J	± kb
transcript	NM_010722	RefSeq \| MGI Sequence Detail	3389	ZRU/MplStud
polypeptide	P21619	UniProt \| EBI \| MGI Sequence Detail	596	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009861 lamin-B2

(term hierarchy)
InterPro Domains

IPR018039 Intermediate filament protein, conserved site

IPR039008 Intermediate filament, rod domain

IPR001322 Lamin tail domain

IPR036415 Lamin tail domain superfamily
GlyGen

P21619 1 site

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All nucleic 73

Genomic 8

cDNA 62

Primer pair 3

Microarray probesets 5

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MGD-MRK-11820

Summaries

All 79

Developmental Gene Expression 21

Gene Ontology 9

Phenotypes 25
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lmnb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98532	Chr10:80754046-80754090 (-)	11 bp
Tssr98531	Chr10:80754016-80754043 (-)	49 bp
Tssr98530	Chr10:80753901-80753912 (-)	172 bp
Tssr98529	Chr10:80753882-80753894 (-)	191 bp
Tssr98528	Chr10:80742257-80742276 (-)	11,812 bp
Tssr98527	Chr10:80742244-80742250 (-)	11,832 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24