Lpn3 QTL Detail

Summary

• Symbol
  Lpn3
• Name
  NZ lupus nephritis 3
• Synonyms
  LN-3, Lpn-3

• Feature Type
  QTL
• IDs
  MGI:96823
  NCBI Gene: 104189

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Mutations,
Alleles, and
Phenotypes

NZB and NZW do not develop lupus nephritis, but F1 progeny and backcrosses to parental strains do. Combined dominant alleles at Lpn1, Lpn2 and Lpn3 determine disease susceptibility. NZW alleles are dominant for Lpn2 and Lpn3 and recessive for Lpn1.

Sequences &
Gene Models

• NCBI Gene
  104189

Other
Accession IDs

MGD-MRK-11837, MGD-MRK-11874, MGD-MRK-11877

References

• Summaries
  All 5
• Earliest
  J:6026 Knight JG, et al., Three genes for lupus nephritis in NZB x NZW mice. J Exp Med. 1978 Jun 1;147(6):1653-60
• Latest
  J:7111 Hirose S, et al., Enhancing effect of H-2-linked NZW gene(s) on the autoimmune traits of (NZB X NZW)F1 mice. J Exp Med. 1983 Jul 1;158(1):228-33