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Selenbp1 Gene Detail
Summary
  • Symbol
    Selenbp1
  • Name
    selenium binding protein 1
  • Synonyms
    Lp56, Lpsb
  • Feature Type
    protein coding gene
  • IDs
    MGI:96825
    NCBI Gene: 20341
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:94840394-94852069 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    393 from dbSNP Build 142
  • Strain Annotations
    13
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96825
 protein coding gene Chr3:94840367-94852069 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0027519
 protein coding gene Chr3:92652293-92672954 (+)
AKR/J MGP_AKRJ_G0027483
 protein coding gene Chr3:94496137-94545401 (+)
BALB/cJ MGP_BALBcJ_G0027528
 protein coding gene Chr3:92129604-92130982 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0027980
 protein coding gene Chr3:99159372-99170483 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0026714
 protein coding gene Chr3:94372569-94383936 (+)
CBA/J MGP_CBAJ_G0027242
 protein coding gene Chr3:102733678-102768587 (+)
DBA/2J MGP_DBA2J_G0027380
 protein coding gene Chr3:91945485-91965410 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0027487
 protein coding gene Chr3:96619051-96638922 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0028031
 protein coding gene Chr3:94187737-94195891 (+)
PWK/PhJ MGP_PWKPhJ_G0026439
 protein coding gene Chr3:91587098-91608938 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026263
 protein coding gene Chr3:92709972-92756330 (+)
WSB/EiJ MGP_WSBEiJ_G0026797
 protein coding gene Chr3:94841919-94852780 (+)



Homology
more
  • Human Ortholog
    SELENBP1, selenium binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SELENBP1, selenium binding protein 1
  • Synonyms
    EHMTO, HEL-S-134P, hSBP, LPSB, MTO, SBP56, SP56
  • Links
    NCBI Gene ID: 8991
    neXtProt AC: NX_Q13228
    UniProt: Q13228

  • Chr Location
    1q21.3; chr1:151364304-151372707 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit sex-specific changes in organ weights. Mice homozygous for a different allele lack methanethiol oxidase activity and exhibit an increase in dimethylsulfide and dimethyl-sulfone serum levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    14
  • cDNA Data
    202
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20341 NCBI Gene Model | MGI Sequence Detail 11676 C57BL/6J ±  kb
    transcript NM_009150 RefSeq | MGI Sequence Detail 1685 ZRU/MplStud  
    polypeptide P17563 UniProt | EBI | MGI Sequence Detail 472 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
      1.8.3.4
    • InterPro Domains
      IPR008826 Selenium-binding protein
    • GlyGen
      P17563 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 207
      Genomic 1
      cDNA 203
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11868, MGD-MRK-11880
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:10796 Bansal MP, et al., DNA sequencing of a mouse liver protein that binds selenium: implications for selenium's mechanism of action in cancer prevention. Carcinogenesis. 1990 Nov;11(11):2071-3
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory