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Lta4h Gene Detail
Summary
  • Symbol
    Lta4h
  • Name
    leukotriene A4 hydrolase
  • Synonyms
    LTA4 hydrodase
  • Feature Type
    protein coding gene
  • IDs
    MGI:96836
    NCBI Gene: 16993
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:93289273-93320737 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 48.42 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1093 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96836
 protein coding gene Chr10:93289258-93320758 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017650
 protein coding gene Chr10:94868283-94902766 (+)
A/J MGP_AJ_G0017629
 protein coding gene Chr10:91565413-91599375 (+)
AKR/J MGP_AKRJ_G0017587
 protein coding gene Chr10:94178876-94221604 (+)
BALB/cJ MGP_BALBcJ_G0017592
 protein coding gene Chr10:91831753-91867136 (+)
C3H/HeJ MGP_C3HHeJ_G0017415
 protein coding gene Chr10:94188932-94227146 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018049
 protein coding gene Chr10:97976555-98010759 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015731
 protein coding gene Chr10:87165521-87198836 (+)
CAST/EiJ MGP_CASTEiJ_G0016980
 protein coding gene Chr10:94152155-94185345 (+)
CBA/J MGP_CBAJ_G0017384
 protein coding gene Chr10:102053546-102097464 (+)
DBA/2J MGP_DBA2J_G0017490
 protein coding gene Chr10:90658014-90696811 (+)
FVB/NJ MGP_FVBNJ_G0017482
 protein coding gene Chr10:89873969-89906439 (+)
LP/J MGP_LPJ_G0017564
 protein coding gene Chr10:95492694-95527914 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017513
 protein coding gene Chr10:103368916-103404447 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018086
 protein coding gene Chr10:94073103-94107725 (+)
PWK/PhJ MGP_PWKPhJ_G0016761
 protein coding gene Chr10:90742783-90775931 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016549
 protein coding gene Chr10:92873674-92906851 (+)
WSB/EiJ MGP_WSBEiJ_G0017039
 protein coding gene Chr10:94046758-94083345 (+)



Homology
more
  • Human Ortholog
    LTA4H, leukotriene A4 hydrolase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LTA4H, leukotriene A4 hydrolase
  • Links
    NCBI Gene ID: 4048
    neXtProt AC: NX_P09960
    UniProt: P09960

  • Chr Location
    12q23.1; chr12:96000753-96043520 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have grossly normal phenotypes. Inflammatory reactions are reduced as are some other immunological responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    110
  • cDNA Data
    148
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015889 Ensembl Gene Model | MGI Sequence Detail 31465 C57BL/6J ±  kb
    transcript ENSMUST00000016033 Ensembl | MGI Sequence Detail 2029 Not Applicable  
    polypeptide ENSMUSP00000016033 Ensembl | MGI Sequence Detail 611 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000009972 leukotriene A-4 hydrolase
      (term hierarchy)
    • EC
      3.3.2.6, 3.4.11.4
    • InterPro Domains
      IPR034015 Aminopeptidase, leukotriene A4 hydrolase-like
      IPR045357 Aminopeptidase N-like , N-terminal domain
      IPR042097 Aminopeptidase N-like , N-terminal domain superfamliy
      IPR016024 Armadillo-type fold
      IPR012777 Leukotriene A4 hydrolase/leucine aminopeptidase
      IPR049980 Leukotriene A4 hydrolase-like, catalytic domain
      IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
      IPR015211 Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal
      IPR038502 Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily
      IPR014782 Peptidase M1, membrane alanine aminopeptidase
      IPR027268 Peptidase M4/M1, CTD superfamily
    • GlyGen
      P24527 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 152
      cDNA 150
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11898
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 37
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory