Ltf MGI Mouse Gene Detail - MGI:96837

Symbol

Ltf
Name

lactotransferrin
Synonyms

lactoferrin, Lf

Feature Type

protein coding gene
IDs

MGI:96837
NCBI Gene: 17002
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr9:110848360-110871834 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 60.79 cM, cytoband F
Mapping Data

7 experiments

SNPs within 2kb

901 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96837	protein coding gene	Chr9:110848339-110871835 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035368	protein coding gene	Chr9:113216147-113243304 (+)
A/J	MGP_AJ_G0035349	protein coding gene	Chr9:109088089-109111521 (+)
AKR/J	MGP_AKRJ_G0035280	protein coding gene	Chr9:111808128-111831440 (+)
BALB/cJ	MGP_BALBcJ_G0035344	protein coding gene	Chr9:108838627-108864194 (+)
C3H/HeJ	MGP_C3HHeJ_G0035052	protein coding gene	Chr9:112307055-112333008 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035866	protein coding gene	Chr9:116348335-116373309 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032752	protein coding gene	Chr9:106299323-106322873 (+)
CAST/EiJ	MGP_CASTEiJ_G0034358	protein coding gene	Chr9:112109616-112136021 (+)
CBA/J	MGP_CBAJ_G0035019	protein coding gene	Chr9:120620277-120654517 (+)
DBA/2J	MGP_DBA2J_G0035178	protein coding gene	Chr9:108542600-108566197 (+)
FVB/NJ	MGP_FVBNJ_G0035125	protein coding gene	Chr9:107387324-107412348 (+)
LP/J	MGP_LPJ_G0035257	protein coding gene	Chr9:113507567-113531708 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035165	protein coding gene	Chr9:121941677-121968672 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035886	protein coding gene	Chr9:112152999-112180647 (+)
PWK/PhJ	MGP_PWKPhJ_G0034065	protein coding gene	Chr9:108788778-108813368 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033900	protein coding gene	Chr9:112239801-112268065 (+)
WSB/EiJ	MGP_WSBEiJ_G0034479	protein coding gene	Chr9:112021566-112046369 (+)

Human Ortholog

LTF, lactotransferrin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LTF, lactotransferrin
Synonyms

GIG12, HEL110, HLF2, LF
Links

HGNC:6720

NCBI Gene ID: 4057

neXtProt AC: NX_P02788

UniProt: P02788
Chr Location

3p21.31; chr3:46435645-46485234 (-) GRCh38

MGI Vertebrate Homology

Ltf stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LTF
Protein SuperFamily

Transferrin
Gene Tree

Ltf

Diseases

3 with human LTF associations

				Human Disease	Mouse Models
				candidiasis IDs candidiasis DOID:1508 DOID:1507 ICD10CM:B37 ICD9CM:112 ICD9CM:112.9 ICD9CM_2006:112.5 MESH:D002177 NCI:C26711 UMLS_CUI:C0006840
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				renal cell carcinoma IDs renal cell carcinoma DOID:4450 EFO:0000681 MESH:D002292 NCI:C9385 OMIM:300854 ORDO:217071 UMLS_CUI:C0007134

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotypes from multigenic genotypes
2 images
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

6
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele are viable, fertile, and grossly normal and exhibit only minor alterations in iron homeostasis. Mice homozygous for a different knock-out allele show increased susceptibility to inflammation-induced colorectal dysplasia along with increased cell proliferation and decreased apoptosis in colonic tissues.

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All GO Annotations

81
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

52
cDNA Data

1666
Literature Summary

21

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TF

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All Sequences

75
RefSeq

2
UniProt

14
CCDS

CCDS23581.1

Ensembl

ENSMUSG00000032496 (Evidence)
NCBI Gene

17002

			Length	Strain/Species	Flank
genomic	17002	NCBI Gene Model \| MGI Sequence Detail	23475	C57BL/6J	± kb
transcript	NM_008522	RefSeq \| MGI Sequence Detail	2742	ZRU/MplStud
polypeptide	P08071	UniProt \| EBI \| MGI Sequence Detail	707	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000009978 lactotransferrin

(term hierarchy)
EC

3.4.21.-
InterPro Domains

IPR030684 Lactotransferrin

IPR016357 Transferrin

IPR018195 Transferrin family, iron binding site

IPR001156 Transferrin-like domain
GlyGen

P08071 2 sites, 1 N-linked glycan (1 site)

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All nucleic 1684

Genomic 11

cDNA 1667

Primer pair 6

Microarray probesets 3

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MGD-MRK-11899

Summaries

All 104

Developmental Gene Expression 21

Gene Ontology 9

Phenotypes 38
Earliest

J:8905 Teng CT, et al., Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9. Somat Cell Mol Genet. 1987 Nov;13(6):689-93
Latest

J:338821 Li R, et al., TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 Aug 1;14(1):4605

TSS for Ltf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87456	Chr9:110848352-110848366 (+)	-1 bp
Tssr87457	Chr9:110850011-110850028 (+)	1,660 bp
Tssr87458	Chr9:110851040-110851059 (+)	2,690 bp
Tssr87459	Chr9:110851458-110851469 (+)	3,104 bp
Tssr3037	Chr9:110852617-110852660 (+)	4,279 bp
Tssr87460	Chr9:110853450-110853460 (+)	5,095 bp
Tssr3038	Chr9:110853535-110853554 (+)	5,185 bp
Tssr87461	Chr9:110854103-110854116 (+)	5,750 bp
Tssr87462	Chr9:110854188-110854199 (+)	5,834 bp
Tssr87463	Chr9:110856398-110856407 (+)	8,043 bp
Tssr87464	Chr9:110856426-110856440 (+)	8,073 bp
Tssr87465	Chr9:110858662-110858672 (+)	10,307 bp
Tssr87466	Chr9:110862050-110862059 (+)	13,695 bp
Tssr87467	Chr9:110864805-110864818 (+)	16,452 bp
Tssr87468	Chr9:110867797-110867804 (+)	19,441 bp
Tssr87469	Chr9:110867810-110867818 (+)	19,454 bp
Tssr87470	Chr9:110867957-110867969 (+)	19,603 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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