Ltk MGI Mouse Gene Detail - MGI:96840 - leukocyte tyrosine kinase

Symbol

Ltk
Name

leukocyte tyrosine kinase

Feature Type

protein coding gene
IDs

MGI:96840
NCBI Gene: 17005
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:119581807-119590912 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 59.97 cM
Mapping Data

18 experiments

SNPs within 2kb

257 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96840	protein coding gene	Chr2:119581801-119590912 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026351	protein coding gene	Chr2:122581767-122590756 (-)
A/J	MGP_AJ_G0026312	protein coding gene	Chr2:117560330-117569281 (-)
AKR/J	MGP_AKRJ_G0026291	protein coding gene	Chr2:120842604-120851619 (-)
BALB/cJ	MGP_BALBcJ_G0026325	protein coding gene	Chr2:117801607-117810558 (-)
C3H/HeJ	MGP_C3HHeJ_G0026071	protein coding gene	Chr2:121304450-121313444 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026772	protein coding gene	Chr2:126568602-126577713 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024152	protein coding gene	Chr2:112588516-112597925 (-)
CAST/EiJ	MGP_CASTEiJ_G0025533	protein coding gene	Chr2:121624824-121633805 (-)
CBA/J	MGP_CBAJ_G0026047	protein coding gene	Chr2:131013492-131022486 (-)
DBA/2J	MGP_DBA2J_G0026186	protein coding gene	Chr2:116956924-116965875 (-)
FVB/NJ	MGP_FVBNJ_G0026148	protein coding gene	Chr2:115788185-115797173 (-)
LP/J	MGP_LPJ_G0026287	protein coding gene	Chr2:122846748-122855735 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026167	protein coding gene	Chr2:135334050-135343050 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026827	protein coding gene	Chr2:120962648-120971642 (-)
PWK/PhJ	MGP_PWKPhJ_G0025269	protein coding gene	Chr2:116541560-116550728 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025068	protein coding gene	Chr2:120148528-120158423 (-)
WSB/EiJ	MGP_WSBEiJ_G0025602	protein coding gene	Chr2:121795920-121804900 (-)

Human Ortholog

LTK, leukocyte receptor tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LTK, leukocyte receptor tyrosine kinase
Synonyms

TYK1
Links

HGNC:6721

NCBI Gene ID: 4058

neXtProt AC: NX_P29376

UniProt: P29376
Chr Location

15q15.1; chr15:41503637-41513887 (-) GRCh38

MGI Vertebrate Homology

Ltk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LTK
Gene Tree

Ltk

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Ltk
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

67
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

29
cDNA Data

14
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LTK

ZFIN ltk

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All Sequences

50
RefSeq

8
UniProt

5
CCDS

CCDS16608.1, CCDS16609.1, CCDS50674.1

Ensembl

ENSMUSG00000027297 (Evidence)
NCBI Gene

17005

			Length	Strain/Species	Flank
genomic	17005	NCBI Gene Model \| MGI Sequence Detail	9106	C57BL/6J	± kb
transcript	NM_203345	RefSeq \| MGI Sequence Detail	3115	Not Specified
polypeptide	P08923	UniProt \| EBI \| MGI Sequence Detail	888	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009979 leukocyte tyrosine kinase receptor

(term hierarchy)
EC

2.7.10.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050122 Receptor Tyrosine Kinase

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
GlyGen

P08923 2 sites

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All nucleic 22

Genomic 4

cDNA 15

Primer pair 3

Microarray probesets 3

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MGD-MRK-11904

Summaries

All 65

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ltk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25828	Chr2:119590890-119590902 (-)	16 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24