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Alad Gene Detail
Summary
  • Symbol
    Alad
  • Name
    aminolevulinate, delta-, dehydratase
  • Synonyms
    Lv
  • Feature Type
    protein coding gene
  • IDs
    MGI:96853
    NCBI Gene: 17025
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:62427406-62438155 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 33.17 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    362 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96853
 protein coding gene Chr4:62422762-62438300 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028356
 protein coding gene Chr4:61492022-61504318 (-)
A/J MGP_AJ_G0028317
 protein coding gene Chr4:59265346-59278814 (-)
AKR/J MGP_AKRJ_G0028266
 protein coding gene Chr4:60911913-60923248 (-)
BALB/cJ MGP_BALBcJ_G0028337
 protein coding gene Chr4:59444319-59455731 (-)
C3H/HeJ MGP_C3HHeJ_G0028055
 protein coding gene Chr4:61414081-61425328 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028777
 protein coding gene Chr4:63609549-63621677 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026083
 protein coding gene Chr4:56552678-56567530 (-)
CAST/EiJ MGP_CASTEiJ_G0027491
 protein coding gene Chr4:59356067-59366606 (-)
CBA/J MGP_CBAJ_G0028023
 protein coding gene Chr4:65810016-65824547 (-)
DBA/2J MGP_DBA2J_G0028173
 protein coding gene Chr4:59128424-59142584 (-)
FVB/NJ MGP_FVBNJ_G0028137
 protein coding gene Chr4:58375506-58387533 (-)
LP/J MGP_LPJ_G0028269
 protein coding gene Chr4:61770727-61781373 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028164
 protein coding gene Chr4:68935647-68949073 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028813
 protein coding gene Chr4:61012968-61024264 (-)
PWK/PhJ MGP_PWKPhJ_G0027218
 protein coding gene Chr4:57603682-57617053 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027047
 protein coding gene Chr4:58461457-58471770 (-)
WSB/EiJ MGP_WSBEiJ_G0027571
 protein coding gene Chr4:60993572-61005108 (-)



Homology
more
  • Human Ortholog
    ALAD, aminolevulinate dehydratase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALAD, aminolevulinate dehydratase
  • Synonyms
    ALADH, PBGS
  • Links
    NCBI Gene ID: 210
    neXtProt AC: NX_P13716
    UniProt: P13716

  • Chr Location
    9q32; chr9:113386312-113401290 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ALAD associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    101
  • cDNA Data
    15
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028393 Ensembl Gene Model | MGI Sequence Detail 10750 C57BL/6J ±  kb
    transcript ENSMUST00000030090 Ensembl | MGI Sequence Detail 1206 Not Applicable  
    polypeptide ENSMUSP00000030090 Ensembl | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 14
      cDNA 21
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11931
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:14972 Russell RL, et al., Genetic control of hepatic delta-aminolevulinate dehydratase in mice. Genetics. 1963 Aug;48:1033-39
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory