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Klrb1 Gene Detail
Summary
  • Symbol
    Klrb1
  • Name
    killer cell lectin-like receptor subfamily B member 1
  • Synonyms
    4930431A04Rik, Gm4696, Ly-55, Ly55, Nkrp1g
  • Feature Type
    protein coding gene
  • IDs
    MGI:96877
    NCBI Gene: 100043861
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128682799-128700022 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.08 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    684 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96877
 protein coding gene Chr6:128682799-128701293 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031334
 protein coding gene Chr6:132340235-132360324 (-)
A/J MGP_AJ_G0031305
 protein coding gene Chr6:127270322-127288807 (-)
AKR/J MGP_AKRJ_G0031232
 protein coding gene Chr6:130693061-130711405 (-)
BALB/cJ MGP_BALBcJ_G0031312
 protein coding gene Chr6:126863755-126884931 (-)
C3H/HeJ MGP_C3HHeJ_G0031036
 protein coding gene Chr6:130863718-130883024 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031769
 protein coding gene Chr6:135781566-135815472 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028914
 protein coding gene Chr6:124603279-124619908 (-)
CAST/EiJ MGP_CASTEiJ_G0030415
 protein coding gene Chr6:131107896-131129222 (-)
CBA/J MGP_CBAJ_G0030997
 protein coding gene Chr6:141048980-141073101 (-)
DBA/2J MGP_DBA2J_G0031151
 protein coding gene Chr6:126179813-126199170 (-)
FVB/NJ MGP_FVBNJ_G0031101
 protein coding gene Chr6:125082729-125100360 (-)
LP/J MGP_LPJ_G0031234
 protein coding gene Chr6:132476085-132504997 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031139
 protein coding gene Chr6:144866188-144901271 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031802
 protein coding gene Chr6:130709279-130729448 (-)
PWK/PhJ MGP_PWKPhJ_G0030130
 protein coding gene Chr6:124456379-124473823 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029958
 protein coding gene Chr6:128822948-128839311 (-)
WSB/EiJ MGP_WSBEiJ_G0030502
 protein coding gene Chr6:131112897-131132475 (-)



Homology
more
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
  • Synonyms
    CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKR-P1A, NKRP1A
  • Links
    NCBI Gene ID: 3820
    neXtProt AC: NX_Q12918
    UniProt: Q12918

  • Chr Location
    12p13.31; chr12:9594551-9607916 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
This locus encodes a NK cell specific antigen. Four RFLP patterns differing among inbred strains have been identified in reference J:12581.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079299 Ensembl Gene Model | MGI Sequence Detail 17224 C57BL/6J ±  kb
    transcript ENSMUST00000112110 Ensembl | MGI Sequence Detail 724 Not Applicable  
    polypeptide ENSMUSP00000107738 Ensembl | MGI Sequence Detail 214 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000035146 killer cell lectin-like receptor subfamily B member 1G
      (term hierarchy)
    • InterPro Domains
      IPR016187 C-type lectin fold
      IPR001304 C-type lectin-like
      IPR016186 C-type lectin-like/link domain superfamily
      IPR051527 Killer cell lectin-like receptor subfamily B
      IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-11998, MGD-MRK-12041, MGI:1914651, MGI:3782876
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:12581 Yokoyama WM, et al., cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6. J Immunol. 1991 Nov 1;147(9):3229-36
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory