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M6pr Gene Detail
Summary
  • Symbol
    M6pr
  • Name
    mannose-6-phosphate receptor, cation dependent
  • Synonyms
    CD-MPR, Mpr46
  • Feature Type
    protein coding gene
  • IDs
    MGI:96904
    NCBI Gene: 17113
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122285679-122294639 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.52 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    220 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96904
 protein coding gene Chr6:122285679-122294639 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031224
 protein coding gene Chr6:125386270-125394815 (+)
A/J MGP_AJ_G0031193
 protein coding gene Chr6:120638023-120645597 (+)
AKR/J MGP_AKRJ_G0031122
 protein coding gene Chr6:123978184-123987634 (+)
BALB/cJ MGP_BALBcJ_G0031202
 protein coding gene Chr6:120328177-120335838 (+)
C3H/HeJ MGP_C3HHeJ_G0030921
 protein coding gene Chr6:123929067-123937303 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031661
 protein coding gene Chr6:128670891-128679791 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028820
 protein coding gene Chr6:117234058-117249964 (+)
CAST/EiJ MGP_CASTEiJ_G0030311
 protein coding gene Chr6:124157254-124181296 (+)
CBA/J MGP_CBAJ_G0030885
 protein coding gene Chr6:133695855-133703652 (+)
DBA/2J MGP_DBA2J_G0031041
 protein coding gene Chr6:119558761-119568716 (+)
FVB/NJ MGP_FVBNJ_G0030993
 protein coding gene Chr6:118505489-118513121 (+)
LP/J MGP_LPJ_G0031121
 protein coding gene Chr6:125537898-125548210 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031028
 protein coding gene Chr6:137672444-137683482 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031691
 protein coding gene Chr6:123864414-123876632 (+)
PWK/PhJ MGP_PWKPhJ_G0030025
 protein coding gene Chr6:118379654-118389187 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029852
 protein coding gene Chr6:121983654-121994528 (+)
WSB/EiJ MGP_WSBEiJ_G0030393
 protein coding gene Chr6:124168914-124176602 (+)



Homology
more
  • Human Ortholog
    M6PR, mannose-6-phosphate receptor, cation dependent
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    M6PR, mannose-6-phosphate receptor, cation dependent
  • Synonyms
    CD-M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR
  • Links
    NCBI Gene ID: 4074
    neXtProt AC: NX_P20645
    UniProt: P20645

  • Chr Location
    12p13.31; chr12:8940361-8949761 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are fertile and display no visible phenotypic abnormalities; however, serum levels of lysosomal enzymes are elevated.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    100
  • cDNA Data
    21
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17113 NCBI Gene Model | MGI Sequence Detail 8961 C57BL/6J ±  kb
    transcript NM_010749 RefSeq | MGI Sequence Detail 2515 ZRU/MplStud  
    polypeptide P24668 UniProt | EBI | MGI Sequence Detail 278 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000010032 cation-dependent mannose-6-phosphate receptor
      (term hierarchy)
    • InterPro Domains
      IPR000296 Cation-dependent mannose-6-phosphate receptor
      IPR028927 Mannose-6-phosphate receptor
      IPR009011 Mannose-6-phosphate receptor binding domain superfamily
      IPR044865 MRH domain
    • GlyGen
      P24668 5 sites, 15 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 4
      cDNA 22

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12091
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:11205 Ma ZM, et al., Cloning, sequencing, and functional characterization of the murine 46-kDa mannose 6-phosphate receptor. J Biol Chem. 1991 Jun 5;266(16):10589-95
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory