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Marcks Gene Detail
Summary
  • Symbol
    Marcks
  • Name
    myristoylated alanine rich protein kinase C substrate
  • Synonyms
    Macs
  • Feature Type
    protein coding gene
  • IDs
    MGI:96907
    NCBI Gene: 17118
  • Alliance
    gene page
  • Transcription Start Sites
    41 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:37009371-37014916 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 19.49 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96907
 protein coding gene Chr10:37009239-37014922 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017145
 protein coding gene Chr10:35565126-35570662 (-)
A/J MGP_AJ_G0017122
 protein coding gene Chr10:34632960-34638500 (-)
AKR/J MGP_AKRJ_G0017082
 protein coding gene Chr10:35078420-35083962 (-)
BALB/cJ MGP_BALBcJ_G0017085
 protein coding gene Chr10:34590971-34596509 (-)
C3H/HeJ MGP_C3HHeJ_G0016905
 protein coding gene Chr10:35401069-35406628 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017543
 protein coding gene Chr10:36637374-36642920 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015240
 protein coding gene Chr10:32718023-32723594 (-)
CAST/EiJ MGP_CASTEiJ_G0016484
 protein coding gene Chr10:35574143-35579642 (-)
CBA/J MGP_CBAJ_G0016879
 protein coding gene Chr10:38361125-38366650 (-)
DBA/2J MGP_DBA2J_G0016984
 protein coding gene Chr10:34196777-34202313 (-)
FVB/NJ MGP_FVBNJ_G0016979
 protein coding gene Chr10:33684081-33689619 (-)
LP/J MGP_LPJ_G0017061
 protein coding gene Chr10:35536222-35543610 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017009
 protein coding gene Chr10:39114479-39122466 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017579
 protein coding gene Chr10:35041780-35047319 (-)
PWK/PhJ MGP_PWKPhJ_G0016265
 protein coding gene Chr10:33985297-33990860 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016049
 protein coding gene Chr10:34882566-34888102 (-)
WSB/EiJ MGP_WSBEiJ_G0016547
 protein coding gene Chr10:35338103-35346432 (-)



Homology
more
  • Human Ortholog
    MARCKS, myristoylated alanine rich protein kinase C substrate
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARCKS, myristoylated alanine rich protein kinase C substrate
  • Synonyms
    80K-L, MACS, PKCSL, PRKCSL
  • Links
    NCBI Gene ID: 4082
    neXtProt AC: NX_P29966
    UniProt: P29966

  • Chr Location
    6q21; chr6:113857345-113863475 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MARCKS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    3 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit perinatal lethality, absence of the corpus callosum and other forebrain commisures, neuronal ectopia, and defects of cortical and retinal lamination. About one-fourth of fetuses are exencephalic.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    44
  • cDNA Data
    18
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069662 Ensembl Gene Model | MGI Sequence Detail 5546 C57BL/6J ±  kb
    transcript ENSMUST00000092584 Ensembl | MGI Sequence Detail 4048 Not Applicable  
    polypeptide ENSMUSP00000090245 Ensembl | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 4
      cDNA 19
      Primer pair 1
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12095, MGD-MRK-12116
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 20
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:350995 Thowfeequ S, et al., An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration. Dev Cell. 2024 Jun 2;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory