Maff Gene Detail

Summary

• Symbol
  Maff
• Name
  v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

• Feature Type
  protein coding gene
• IDs
  MGI:96910
  NCBI Gene: 17133
• Alliance
  gene page
• Transcription Start Sites
  13 TSS

Location &
Maps

• Sequence Map
  Chr15:79230821-79243276 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 37.70 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  355 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96910	protein coding gene	Chr15:79230813-79243278 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022072	protein coding gene	Chr15:79607216-79620671 (+)
A/J	MGP_AJ_G0022033	protein coding gene	Chr15:76866393-76877910 (+)
AKR/J	MGP_AKRJ_G0022008	protein coding gene	Chr15:79011062-79022578 (+)
BALB/cJ	MGP_BALBcJ_G0022039	protein coding gene	Chr15:76858704-76870264 (+)
C3H/HeJ	MGP_C3HHeJ_G0021810	protein coding gene	Chr15:79006077-79018008 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022482	protein coding gene	Chr15:82759020-82771623 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020012	protein coding gene	Chr15:73347718-73359115 (+)
CAST/EiJ	MGP_CASTEiJ_G0021331	protein coding gene	Chr15:79707804-79720498 (+)
CBA/J	MGP_CBAJ_G0021775	protein coding gene	Chr15:85319561-85331066 (+)
DBA/2J	MGP_DBA2J_G0021904	protein coding gene	Chr15:76349098-76360663 (+)
FVB/NJ	MGP_FVBNJ_G0021882	protein coding gene	Chr15:75380175-75392114 (+)
LP/J	MGP_LPJ_G0021972	protein coding gene	Chr15:79799154-79810675 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021902	protein coding gene	Chr15:90441923-90456466 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022496	protein coding gene	Chr15:79024832-79036391 (+)
PWK/PhJ	MGP_PWKPhJ_G0021073	protein coding gene	Chr15:76357839-76369608 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020910	protein coding gene	Chr15:78833901-78847536 (+)
WSB/EiJ	MGP_WSBEiJ_G0021383	protein coding gene	Chr15:79408703-79420258 (+)

Homology

• Human Ortholog
  MAFF, MAF bZIP transcription factor F

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MAFF, MAF bZIP transcription factor F
  
• Synonyms
  hMafF, U-MAF
• Links
  HGNC:6780

  NCBI Gene ID: 23764

  neXtProt AC: NX_Q9ULX9

  UniProt: Q9ULX9

  
  
• Chr Location
  22q13.1; chr22:38200767-38216511 (+)  GRCh38

---

• MGI Vertebrate Homology
  Maff stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: MAFF
• Gene Tree
  Maff
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 1 genetic background
  35 phenotype references
  

• All Mutations and Alleles
  16
• Chemically induced (other)
  1
• Endonuclease-mediated
  3
• Gene trapped
  4
• Radiation induced
  2
• Targeted
  6
• Genomic Mutations
  3 involving Maff
• Find Mice (IMSR)
  8 strains or lines available

Homozygous null mice are viable and fertile and show no obvious functional deficiencies.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  22
• GO References
  5

Expression

• Assay Results
  886
• Tissues
  172
• cDNA Data
  24
• Literature Summary
  10

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA MAFF
  ZFIN maff

Sequences &
Gene Models

• All Sequences
  56
• RefSeq
  14
• UniProt
  5
• CCDS
  CCDS27638.1

• Ensembl
  ENSMUSG00000042622 (Evidence)
• NCBI Gene
  17133

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000042622	Ensembl Gene Model | MGI Sequence Detail	12456	C57BL/6J
transcript	ENSMUST00000229130	Ensembl | MGI Sequence Detail	1873	Not Applicable
polypeptide	ENSMUSP00000154850	Ensembl | MGI Sequence Detail	156	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000010049 transcription factor MafF
  (term hierarchy)
• InterPro Domains
  IPR004827 Basic-leucine zipper domain
  IPR004826 Basic leucine zipper domain, Maf-type
  IPR046347 Basic-leucine zipper domain superfamily
  IPR024874 Transcription factor Maf family
  IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily

Molecular
Reagents

• All nucleic 28

  Genomic 1

  cDNA 24

  Primer pair 3

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-12102

References

• Summaries
  All 66

  Developmental Gene Expression 10

  Diseases 1

  Gene Ontology 5

  Phenotypes 35
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:350369 Miura H, et al., Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT. BMC Genomics. 2024 Jun 5;25(1):568

TSS for Maff:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132083	Chr15:79230808-79230817 (+)	-8 bp
Tssr132084	Chr15:79231734-79231756 (+)	924 bp
Tssr132085	Chr15:79231767-79231778 (+)	952 bp
Tssr132086	Chr15:79231783-79231798 (+)	970 bp
Tssr132087	Chr15:79231799-79231814 (+)	986 bp
Tssr132088	Chr15:79231830-79231844 (+)	1,016 bp
Tssr132089	Chr15:79232137-79232230 (+)	1,363 bp
Tssr132090	Chr15:79232329-79232354 (+)	1,521 bp
Tssr132091	Chr15:79232591-79232607 (+)	1,778 bp
Tssr132092	Chr15:79232621-79232632 (+)	1,806 bp
Tssr132093	Chr15:79242059-79242070 (+)	11,244 bp
Tssr132094	Chr15:79242590-79242595 (+)	11,772 bp
Tssr132095	Chr15:79242640-79242653 (+)	11,826 bp