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Maoa
Gene Detail
Symbol

Name
ID
Maoa
monoamine oxidase A
MGI:96915
Synonyms
1110061B18Rik, MAO-A, MGC:27811
Feature Type
protein coding gene
Genetic Map
Chromosome X
11.78 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
ChrX:16619698-16687818 bp, + strand
From VEGA annotation of GRCm38

  68121 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Maoa

Human
homologs
Human Homolog MAOA, monoamine oxidase A
NCBI Gene ID 4128
neXtProt AC  NX_P21397
Human Synonyms  MAO-A
Human Chr (Location)  Xp11.3; chrX:43654907-43746824 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human MAOA
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(1) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show reduced LV systolic pressure and resistance to induced cardiac stress. Males hemizygous for a spontaneous allele show intermale aggression and hypoactivity. Hemizygotes for a transgenic gene disruption show altered behavior and adrenocortical response to stress.
 
Human Diseases Modeled Using Mouse Maoa (2)    Alleles Annotated to Human Diseases(2)   
Interactions
Maoa interacts with 312 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process catecholamine metabolic process, dopamine catabolic process, ...
Component integral component of membrane, membrane, ...
Function flavin adenine dinucleotide binding, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (359)    Tissues (143)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 359
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016928 (Evidence)
Ensembl Gene ModelENSMUSG00000025037 (Evidence)
Entrez Gene17161 (Evidence)
DFCITC1576279
DoTSDT.490331, DT.55230094, DT.55248946
NIA Mouse Gene IndexU019731
EC1.4.3.4
Consensus CDS ProjectCCDS30033.1
International Mouse Knockout Project StatusMaoa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016928 VEGA Gene Model | MGI Sequence Detail 68121 C57BL/6J ±  kb
transcript OTTMUST00000041061 VEGA | MGI Sequence Detail 4167 Not Applicable 
polypeptide OTTMUSP00000018396 VEGA | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(230 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002937 Amine oxidase
InterPro IPR001613 Flavin amine oxidase
Protein Ontology PR:000010114 amine oxidase [flavin-containing] A
References
(Earliest) J:10089 Derry JM, et al., Localization of monoamine oxidase A and B genes on the mouse X chromosome. Nucleic Acids Res. 1989 Oct 25;17(20):8403
(Latest) J:212124 St-Louis R, et al., Reactive oxygen species are physiological mediators of the noradrenergic signaling pathway in the mouse supraoptic nucleus. Free Radic Biol Med. 2014 Jun;71:231-9
All references(112)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-12111, MGI:1916081, MGI:2147818

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory