Mas1 MGI Mouse Gene Detail - MGI:96918

Symbol

Mas1
Name

MAS1 oncogene
Synonyms

Mas-1, MasR, Mas receptor

Feature Type

protein coding gene
IDs

MGI:96918
NCBI Gene: 17171
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:13059966-13087030 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.69 cM
Mapping Data

17 experiments

SNPs within 2kb

309 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96918	protein coding gene	Chr17:13056981-13087037 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023150	protein coding gene	Chr17:10505219-10536889 (-)
A/J	MGP_AJ_G0023118	protein coding gene	Chr17:10339227-10366101 (-)
AKR/J	MGP_AKRJ_G0023082	protein coding gene	Chr17:10165966-10197672 (-)
BALB/cJ	MGP_BALBcJ_G0023118	protein coding gene	Chr17:10112258-10139631 (-)
C3H/HeJ	MGP_C3HHeJ_G0022881	protein coding gene	Chr17:10415488-10444562 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023561	protein coding gene	Chr17:10902423-10935876 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021047	protein coding gene	Chr17:4083302-4110366 (+)
CAST/EiJ	MGP_CASTEiJ_G0022395	protein coding gene	Chr17:10498077-10529581 (-)
CBA/J	MGP_CBAJ_G0022853	protein coding gene	Chr17:11322778-11356047 (-)
DBA/2J	MGP_DBA2J_G0022986	protein coding gene	Chr17:9978258-10006448 (-)
FVB/NJ	MGP_FVBNJ_G0022956	protein coding gene	Chr17:9915441-9942753 (-)
LP/J	MGP_LPJ_G0023058	protein coding gene	Chr17:10337792-10366108 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022975	protein coding gene	Chr17:10909289-10943579 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023587	protein coding gene	Chr17:10440539-10471567 (-)
PWK/PhJ	MGP_PWKPhJ_G0022143	protein coding gene	Chr17:9667199-9694893 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021973	protein coding gene	Chr17:9875708-9902606 (-)
WSB/EiJ	MGP_WSBEiJ_G0022452	protein coding gene	Chr17:10753298-10782171 (-)

Human Ortholog

MAS1, MAS1 proto-oncogene, G protein-coupled receptor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAS1, MAS1 proto-oncogene, G protein-coupled receptor
Synonyms

MAS, MGRA
Links

HGNC:6899

NCBI Gene ID: 4142

neXtProt AC: NX_P04201

UniProt: P04201
Chr Location

6q25.3; chr6:159888787-159917447 (+) GRCh38

MGI Vertebrate Homology

Mas1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MAS1
Gene Tree

Mas1

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Phenotype Summary

23 phenotypes from 2 alleles in 3 genetic backgrounds
54 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Targeted

6
Transgenic

2
Genomic Mutations

1 involving Mas1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene show enhanced long term potentiation and higher levels of anxiety. They are otherwise normal and fertile.

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All GO Annotations

36
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

935
Tissues

74
cDNA Data

9
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

78
RefSeq

22
UniProt

6
CCDS

CCDS28394.1

Ensembl

ENSMUSG00000068037 (Evidence)
NCBI Gene

17171

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068037	Ensembl Gene Model \| MGI Sequence Detail	27065	C57BL/6J	± kb
transcript	ENSMUST00000089015	Ensembl \| MGI Sequence Detail	2401	Not Applicable
polypeptide	ENSMUSP00000086409	Ensembl \| MGI Sequence Detail	324	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000001563 G-protein coupled receptor MAS

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR026234 Mas-related G protein-coupled receptor family

IPR000820 Proto-oncogene Mas
GlyGen

P30554 3 sites

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All nucleic 28

Genomic 7

cDNA 11

Primer pair 5

Other 5

Microarray probesets 3

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MGD-MRK-12117, MGD-MRK-12118

Summaries

All 115

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 54
Earliest

J:902 Cebra-Thomas JA, et al., Localization of the Mas proto-oncogene to a densely marked region of mouse chromosome 17 associated with genomic imprinting [published erratum appears in Genomics 1992 Sep;14(1):208]. Genomics. 1992 Jun;13(2):444-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mas1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146454	Chr17:13087013-13087035 (-)	6 bp
Tssr146453	Chr17:13070782-13070803 (-)	16,237 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24