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Mbp Gene Detail
Summary
  • Symbol
    Mbp
  • Name
    myelin basic protein
  • Synonyms
    golli-mbp, Hmbpr, jve
  • Feature Type
    protein coding gene
  • IDs
    MGI:96925
    NCBI Gene: 17196
  • Alliance
    gene page
  • Transcription Start Sites
    45 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:82493271-82603762 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 55.84 cM, cytoband E2-E4
  • Mapping Data
    42 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3454 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
  • RFLP
    22
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96925
 protein coding gene Chr18:82492883-82603762 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024601
 protein coding gene Chr18:83503099-83625563 (+)
A/J MGP_AJ_G0024568
 protein coding gene Chr18:79857765-79975533 (+)
AKR/J MGP_AKRJ_G0024539
 protein coding gene Chr18:82223240-82339100 (+)
BALB/cJ MGP_BALBcJ_G0024566
 protein coding gene Chr18:80046344-80159892 (+)
C3H/HeJ MGP_C3HHeJ_G0024335
 protein coding gene Chr18:82333972-82454397 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025013
 protein coding gene Chr18:85561903-85688547 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022444
 protein coding gene Chr18:78620687-78731252 (+)
CAST/EiJ MGP_CASTEiJ_G0023808
 protein coding gene Chr18:82638906-82760379 (+)
CBA/J MGP_CBAJ_G0024305
 protein coding gene Chr18:88750575-88875395 (+)
DBA/2J MGP_DBA2J_G0024435
 protein coding gene Chr18:79382760-79495264 (+)
FVB/NJ MGP_FVBNJ_G0024401
 protein coding gene Chr18:78687454-78802850 (+)
LP/J MGP_LPJ_G0024519
 protein coding gene Chr18:83320775-83438306 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024431
 protein coding gene Chr18:89967743-90087998 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025062
 protein coding gene Chr18:82398753-82513604 (+)
PWK/PhJ MGP_PWKPhJ_G0023553
 protein coding gene Chr18:79753130-79878926 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023359
 protein coding gene Chr18:82515685-82625844 (+)
WSB/EiJ MGP_WSBEiJ_G0023870
 protein coding gene Chr18:82376809-82496798 (+)



Homology
more
  • Human Ortholog
    MBP, myelin basic protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MBP, myelin basic protein
  • Links
    NCBI Gene ID: 4155
    neXtProt AC: NX_P02686
    UniProt: P02686

  • Chr Location
    18q23; chr18:76978827-77133708 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MBP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 5 alleles in 11 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    172 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show altered myelination, oligodendrocytes, Ca2+ responses, and visual-evoked potentials. Spontaneous mutations cause dymyelination, tremors and ataxia, and may alter survival, susceptibility to seizures, viral infection and EAE, and hearing or vestibular function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1272
  • Tissues
    148
  • cDNA Data
    37
  • Literature Summary
    285
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041607 Ensembl Gene Model | MGI Sequence Detail 110492 C57BL/6J ±  kb
    transcript ENSMUST00000047865 Ensembl | MGI Sequence Detail 2492 Not Applicable  
    polypeptide ENSMUSP00000046185 Ensembl | MGI Sequence Detail 250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 18
      cDNA 42
      Primer pair 22
      Other 28

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-10746, MGD-MRK-12126, MGD-MRK-12253, MGD-MRK-14404, MGI:2147393, MGI:2147422, MGI:3708158
    References
    more
    • Summaries
      All 631
      Developmental Gene Expression 285
      Gene Ontology 21
      Phenotypes 172
    • Earliest
      J:5917 Doolittle DP, et al., Myelin deficient, a new neurological mutant in the mouse. J Hered. 1977 Sep-Oct;68(5):331-2
    • Latest
      J:357652 Bagheri H, et al., Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells. Glia. 2024 Oct;72(10):1893-1914
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory