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Mcf2 Gene Detail
Summary
  • Symbol
    Mcf2
  • Name
    mcf.2 transforming sequence
  • Synonyms
    B230117G22Rik, Dbl
  • Feature Type
    protein coding gene
  • IDs
    MGI:96932
    NCBI Gene: 109904
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:59101316-59224449 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 33.50 cM, cytoband A6/A7
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2318 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96932
 protein coding gene ChrX:59101316-59224546 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035756
 protein coding gene ChrX:55407910-55539892 (-)
A/J MGP_AJ_G0035738
 protein coding gene ChrX:55616915-55743481 (-)
AKR/J MGP_AKRJ_G0035658
 protein coding gene ChrX:57112455-57251692 (-)
BALB/cJ MGP_BALBcJ_G0035725
 protein coding gene ChrX:54983124-55110751 (-)
C3H/HeJ MGP_C3HHeJ_G0035427
 protein coding gene ChrX:55964383-56088643 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036254
 protein coding gene ChrX:56896051-57030177 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033106
 protein coding gene ChrX:55442188-55564311 (-)
CAST/EiJ MGP_CASTEiJ_G0034720
 protein coding gene ChrX:41737782-41864394 (-)
CBA/J MGP_CBAJ_G0035402
 protein coding gene ChrX:58585626-58724685 (-)
DBA/2J MGP_DBA2J_G0035556
 protein coding gene ChrX:55195251-55319515 (-)
FVB/NJ MGP_FVBNJ_G0035506
 protein coding gene ChrX:54737483-54858397 (-)
LP/J MGP_LPJ_G0035644
 protein coding gene ChrX:56004496-56128295 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035542
 protein coding gene ChrX:60153928-60293294 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036270
 protein coding gene ChrX:55443908-55578992 (-)
PWK/PhJ MGP_PWKPhJ_G0034415
 protein coding gene ChrX:39918901-40042800 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034260
 protein coding gene ChrX:42568260-42704849 (-)
WSB/EiJ MGP_WSBEiJ_G0034863
 protein coding gene ChrX:54944031-55062467 (-)



Homology
more
  • Human Ortholog
    MCF2, MCF.2 cell line derived transforming sequence
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCF2, MCF.2 cell line derived transforming sequence
  • Synonyms
    ARHGEF21, DBL
  • Links
    NCBI Gene ID: 4168
    neXtProt AC: NX_P10911
    UniProt: P10911

  • Chr Location
    Xq27.1; chrX:139581770-139708216 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous and hemizygous null mice are viable, fertile and behaviorally normal, exhibit normal gonad and brain development and neuronal migration, but show a significant reduction of basal dendritic length in distinct subpopulations of cortical pyramidal neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    11
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031139 Ensembl Gene Model | MGI Sequence Detail 123134 C57BL/6J ±  kb
transcript ENSMUST00000063507 Ensembl | MGI Sequence Detail 4227 Not Applicable  
polypeptide ENSMUSP00000067075 Ensembl | MGI Sequence Detail 1031 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR001251 CRAL-TRIO lipid binding domain
    IPR000219 Dbl homology (DH) domain
    IPR035899 Dbl homology (DH) domain superfamily
    IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR051336 Rho GTPase-activating Guanine Nucleotide Exchange Factors
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-12134, MGD-MRK-12135, MGI:2444059
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:30981 Eva A, et al., Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature. 1985 Jul 18-24;316(6025):273-5
  • Latest
    J:215939 Gupta M, et al., Tyrosine phosphorylation of Dbl regulates GTPase signaling. J Biol Chem. 2014 Jun 13;289(24):17195-202
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory