Golga3 MGI Mouse Gene Detail - MGI:96958

Symbol

Golga3
Name

golgin A3
Synonyms

5430416E01Rik, G1-499-14, Mea-2, Mea2, repro27

Feature Type

protein coding gene
IDs

MGI:96958
NCBI Gene: 269682
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:110324723-110374336 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 53.36 cM
Mapping Data

6 experiments

SNPs within 2kb

981 from dbSNP Build 142
Strain Annotations

18
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96958	protein coding gene	Chr5:110324567-110374336 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029881	protein coding gene	Chr5:112619726-112668792 (+)
A/J	MGP_AJ_G0029846	protein coding gene	Chr5:108258214-108303689 (+)
AKR/J	MGP_AKRJ_G0029784	protein coding gene	Chr5:111703952-111754524 (+)
BALB/cJ	MGP_BALBcJ_G0029857	protein coding gene	Chr5:109624773-109674203 (+)
C3H/HeJ	MGP_C3HHeJ_G0029577	protein coding gene	Chr5:112130405-112180555 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030310	protein coding gene	Chr5:117063554-117114963 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027539	protein coding gene	Chr5:103084384-103132897 (+)
CAST/EiJ	MGP_CASTEiJ_G0028985	protein coding gene	Chr5:110993730-111041992 (+)
CBA/J	MGP_CBAJ_G0029544	protein coding gene	Chr5:121464885-121520052 (+)
DBA/2J	MGP_DBA2J_G0029694	protein coding gene	Chr5:108325134-108370658 (+)
FVB/NJ	MGP_FVBNJ_G0029651	protein coding gene	Chr5:107000609-107046476 (+)
LP/J	MGP_LPJ_G0029782	protein coding gene	Chr5:113182031-113230166 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029682	protein coding gene	Chr5:126120664-126165286 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030351	protein coding gene	Chr5:111135388-111187185 (+)
PWK/PhJ	MGP_PWKPhJ_G0028699	protein coding gene	Chr5:106914385-106959847 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028537	protein coding gene	Chr5:108603628-108652460 (+)
WSB/EiJ	MGP_WSBEiJ_G0029061	protein coding gene	Chr5:111581986-111638188 (+)

Human Ortholog

GOLGA3, golgin A3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GOLGA3, golgin A3
Synonyms

GCP170, MEA-2
Links

HGNC:4426

NCBI Gene ID: 2802

neXtProt AC: NX_Q08378

UniProt: Q08378
Chr Location

12q24.33; chr12:132768902-132829143 (-) GRCh38

MGI Vertebrate Homology

Golga3 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: GOLGA3
Gene Tree

Golga3

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Phenotype Summary

24 phenotypes from 3 alleles in 4 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Radiation induced

1
Targeted

3
Transgenic

1
Genomic Mutations

2 involving Golga3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

67 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Males homozygous for a hypomorphic transgenic insertional mutation exhibit impaired spermatogenesis involving loss of pachytene spermatocytes and are usually sterile. Male mice homozygous for an ENU-induced mutation exhibit infertility with low sperm concentration, poor motility and abnormal shape.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

21
cDNA Data

21
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase golga3

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All Sequences

59
RefSeq

10
UniProt

5
CCDS

CCDS39209.1, CCDS84928.1

Ensembl

ENSMUSG00000029502 (Evidence)
NCBI Gene

269682

			Length	Strain/Species	Flank
genomic	269682	NCBI Gene Model \| MGI Sequence Detail	49614	C57BL/6J	± kb
transcript	NM_001347389	RefSeq \| MGI Sequence Detail	8096	ZRU/MplStud
polypeptide	P55937	UniProt \| EBI \| MGI Sequence Detail	1487	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008132 golgin subfamily A member 3

(term hierarchy)
InterPro Domains

IPR051841 Microtubule and Golgi organization protein
GlyGen

P55937 1 site, 1 O-linked glycan (1 site)

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All nucleic 21

cDNA 21

Microarray probesets 7

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MGD-MRK-12184, MGD-MRK-12186, MGI:1918641, MGI:2140889, MGI:2141196, MGI:3512808

Summaries

All 55

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 20
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Golga3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47872	Chr5:110324419-110324431 (+)	-298 bp
Tssr47873	Chr5:110324445-110324466 (+)	-267 bp
Tssr47874	Chr5:110324506-110324544 (+)	-198 bp
Tssr47875	Chr5:110324677-110324686 (+)	-41 bp
Tssr47876	Chr5:110324716-110324730 (+)	0 bp
Tssr47877	Chr5:110324734-110324762 (+)	25 bp
Tssr47878	Chr5:110324830-110324839 (+)	112 bp
Tssr47879	Chr5:110328897-110328898 (+)	4,175 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24