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Mest Gene Detail
Summary
  • Symbol
    Mest
  • Name
    mesoderm specific transcript
  • Synonyms
    Peg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96968
    NCBI Gene: 17294
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:30723546-30748464 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.53 cM, cytoband B1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    569 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96968
 protein coding gene Chr6:30723546-30783580 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030544
 protein coding gene Chr6:28626364-28652729 (+)
A/J MGP_AJ_G0030517
 protein coding gene Chr6:27399058-27423915 (+)
AKR/J MGP_AKRJ_G0030444
 protein coding gene Chr6:28311694-28336513 (+)
BALB/cJ MGP_BALBcJ_G0030527
 protein coding gene Chr6:27544131-27569333 (+)
C3H/HeJ MGP_C3HHeJ_G0030240
 protein coding gene Chr6:28304183-28328666 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030981
 protein coding gene Chr6:29443876-29477882 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028192
 protein coding gene Chr6:25587210-25612667 (+)
CAST/EiJ MGP_CASTEiJ_G0029642
 protein coding gene Chr6:28123886-28152051 (+)
CBA/J MGP_CBAJ_G0030218
 protein coding gene Chr6:30558506-30588736 (+)
DBA/2J MGP_DBA2J_G0030362
 protein coding gene Chr6:27330263-27354791 (+)
FVB/NJ MGP_FVBNJ_G0030316
 protein coding gene Chr6:27091062-27118401 (+)
LP/J MGP_LPJ_G0030449
 protein coding gene Chr6:28758468-28786852 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030352
 protein coding gene Chr6:32991244-33017630 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031011
 protein coding gene Chr6:28184954-28210147 (+)
PWK/PhJ MGP_PWKPhJ_G0029356
 protein coding gene Chr6:26902660-26928327 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029192
 protein coding gene Chr6:27935555-27961451 (+)
WSB/EiJ MGP_WSBEiJ_G0029718
 protein coding gene Chr6:28155578-28180984 (+)



Homology
more
  • Human Ortholog
    MEST, mesoderm specific transcript
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEST, mesoderm specific transcript
  • Synonyms
    PEG1
  • Links
    NCBI Gene ID: 4232
    neXtProt AC: NX_Q5EB52
    UniProt: Q5EB52

  • Chr Location
    7q32.2; chr7:130486171-130506465 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mest mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit retardation of embryonic growth and subtle cardiac abnormalities associated with reduced postnatal survival rates. Mutant females exhibit abnormal maternal behavior and impaired placentophagia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1105
  • Tissues
    208
  • cDNA Data
    29
  • Literature Summary
    85
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051855 Ensembl Gene Model | MGI Sequence Detail 24919 C57BL/6J ±  kb
    transcript ENSMUST00000124665 Ensembl | MGI Sequence Detail 2665 Not Applicable  
    polypeptide ENSMUSP00000117713 Ensembl | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 7
      cDNA 33
      Primer pair 15
      Other 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12202, MGI:1353588, MGI:2141362
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 85
      Diseases 1
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:16422 Sado T, et al., A novel Mesoderm-Specific cDNA isolated from a mouse embryonal carcinoma cell line. Dev Growth Differ. 1993 Oct;35(5):551-60
    • Latest
      J:347974 Zhou B, et al., Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos. Dev Cell. 2024 Apr 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory