Mgat1 MGI Mouse Gene Detail - MGI:96973 - mannoside acetylglucosaminyltransferase 1

Symbol

Mgat1
Name

mannoside acetylglucosaminyltransferase 1
Synonyms

Mgat-1

Feature Type

protein coding gene
IDs

MGI:96973
NCBI Gene: 17308
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:49135018-49153854 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 29.27 cM
Mapping Data

24 experiments

SNPs within 2kb

498 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96973	protein coding gene	Chr11:49135018-49153857 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018223	protein coding gene	Chr11:48309742-48329727 (+)
A/J	MGP_AJ_G0018193	protein coding gene	Chr11:46449902-46468811 (+)
AKR/J	MGP_AKRJ_G0018160	protein coding gene	Chr11:47901062-47919876 (+)
BALB/cJ	MGP_BALBcJ_G0018162	protein coding gene	Chr11:46707168-46725728 (+)
C3H/HeJ	MGP_C3HHeJ_G0017976	protein coding gene	Chr11:47931940-47950619 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018613	protein coding gene	Chr11:49773806-49800228 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016267	protein coding gene	Chr11:44154121-44172601 (+)
CAST/EiJ	MGP_CASTEiJ_G0017539	protein coding gene	Chr11:47987381-48006619 (+)
CBA/J	MGP_CBAJ_G0017948	protein coding gene	Chr11:52083897-52102620 (+)
DBA/2J	MGP_DBA2J_G0018057	protein coding gene	Chr11:46307251-46326032 (+)
FVB/NJ	MGP_FVBNJ_G0018052	protein coding gene	Chr11:45901340-45919929 (+)
LP/J	MGP_LPJ_G0018131	protein coding gene	Chr11:48632441-48651778 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018076	protein coding gene	Chr11:53598555-53617382 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018656	protein coding gene	Chr11:48029722-48048522 (+)
PWK/PhJ	MGP_PWKPhJ_G0017318	protein coding gene	Chr11:46637580-46656318 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017112	protein coding gene	Chr11:47711966-47734337 (+)
WSB/EiJ	MGP_WSBEiJ_G0017590	protein coding gene	Chr11:47685987-47704969 (+)

Human Ortholog

MGAT1, alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MGAT1, alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms

GLCNAC-TI, GLCT1, GLYT1, GNT-1, GnTI, GNT-I, MGAT
Links

HGNC:7044

NCBI Gene ID: 4245

neXtProt AC: NX_P26572

UniProt: P26572
Chr Location

5q35.3; chr5:180784780-180815652 (-) GRCh38

MGI Vertebrate Homology

Mgat1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MGAT1
Gene Tree

Mgat1

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Phenotype Summary

33 phenotypes from 4 alleles in 6 genetic backgrounds
22 phenotypes from multigenic genotypes
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Targeted

6
Genomic Mutations

1 involving Mgat1
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations develop a deficiency of complex N-glycans during embryogenesis, exhibit defects of neural tube formation, vascularization, and left-right body axis determination, and die by embryonic day 10.5.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

833
Tissues

103
cDNA Data

132
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mgat1

ZFIN mgat1b

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All Sequences

85
RefSeq

24
UniProt

4
CCDS

CCDS24602.1

Ensembl

ENSMUSG00000020346 (Evidence)
NCBI Gene

17308

			Length	Strain/Species	Flank
genomic	17308	NCBI Gene Model \| MGI Sequence Detail	18837	C57BL/6J	± kb
transcript	NM_001110148	RefSeq \| MGI Sequence Detail	3165	ZRU/MplStud
polypeptide	P27808	UniProt \| EBI \| MGI Sequence Detail	447	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010378 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

(term hierarchy)
EC

2.4.1.101
InterPro Domains

IPR052261 Glycosyltransferase 13

IPR004139 Glycosyl transferase, family 13

IPR029044 Nucleotide-diphospho-sugar transferases

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All nucleic 142

Genomic 7

cDNA 133

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-12217, MGD-MRK-12218

Summaries

All 81

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 36
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mgat1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101180	Chr11:49135054-49135110 (+)	64 bp
Tssr101181	Chr11:49136285-49136333 (+)	1,291 bp
Tssr101182	Chr11:49136351-49136366 (+)	1,341 bp
Tssr101183	Chr11:49138289-49138339 (+)	3,296 bp
Tssr101184	Chr11:49140924-49140942 (+)	5,915 bp
Tssr101185	Chr11:49141369-49141399 (+)	6,366 bp
Tssr101186	Chr11:49141410-49141424 (+)	6,399 bp
Tssr101187	Chr11:49149867-49149878 (+)	14,855 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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