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Mmp3 Gene Detail
Summary
  • Symbol
    Mmp3
  • Name
    matrix metallopeptidase 3
  • Synonyms
    progelatinase, SLN-1, SLN1, Stmy1, Str1, STR-1, stromelysin 1, stromelysin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97010
    NCBI Gene: 17392
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7445845-7455975 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97010
 protein coding gene Chr9:7445822-7455975 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034321
 protein coding gene Chr9:4308438-4319058 (+)
A/J MGP_AJ_G0034298
 protein coding gene Chr9:4399013-4409808 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0034292
 protein coding gene Chr9:4139349-4155036 (+)
C3H/HeJ MGP_C3HHeJ_G0034004
 protein coding gene Chr9:4475156-4485919 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034815
 protein coding gene Chr9:4469008-4480331 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031752
 protein coding gene Chr9:3697904-3707840 (+)
CAST/EiJ MGP_CASTEiJ_G0033333
 protein coding gene Chr9:4484059-4494762 (+)
CBA/J MGP_CBAJ_G0033977
 protein coding gene Chr9:4569728-4580014 (+)
DBA/2J MGP_DBA2J_G0034133
 protein coding gene Chr9:4290085-4315930 (+)
FVB/NJ MGP_FVBNJ_G0034079
 protein coding gene Chr9:4062377-4072623 (+)
LP/J MGP_LPJ_G0034220
 protein coding gene Chr9:4351579-4363065 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034123
 protein coding gene Chr9:5282476-5293668 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034833
 protein coding gene Chr9:4270088-4284412 (+)
PWK/PhJ MGP_PWKPhJ_G0033035
 protein coding gene Chr9:4430273-4441707 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032872
 protein coding gene Chr9:4521491-4532730 (+)
WSB/EiJ MGP_WSBEiJ_G0033447
 protein coding gene Chr9:4278186-4290321 (+)



Homology
more
  • Human Ortholog
    MMP3, matrix metallopeptidase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP3, matrix metallopeptidase 3
  • Synonyms
    CHDS6, MMP-3, SL-1, STMY, STMY1, STR1
  • Links
    NCBI Gene ID: 4314
    neXtProt AC: NX_P08254
    UniProt: P08254

  • Chr Location
    11q22.2; chr11:102835801-102843609 (-)  GRCh38
Human Diseases
more
  • Diseases
    13 with human MMP3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disrutptions in this gene display abnormalities of the immune system as well as minor structural abnormalities in the neuromuscular junction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    33
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    43
  • cDNA Data
    13
  • Literature Summary
    45
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17392 NCBI Gene Model | MGI Sequence Detail 10131 C57BL/6J ±  kb
    transcript NM_010809 RefSeq | MGI Sequence Detail 1778 ZRU/MplStud  
    polypeptide P28862 UniProt | EBI | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 4
      cDNA 14
      Primer pair 11
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12280, MGD-MRK-14627
    References
    more
    • Summaries
      All 165
      Developmental Gene Expression 45
      Gene Ontology 11
      Phenotypes 44
    • Earliest
      J:2890 Hammani K, et al., Cloning and sequencing of a cDNA encoding mouse stromelysin 1. Gene. 1992 Oct 21;120(2):321-2
    • Latest
      J:347984 Naillat F, et al., Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory