Mmp9 MGI Mouse Gene Detail - MGI:97011 - matrix metallopeptidase 9

Symbol

Mmp9
Name

matrix metallopeptidase 9
Synonyms

B/MMP9, Clg4b, gelatinase B, Gelatinase B, Gel B, MMP-9

Feature Type

protein coding gene
IDs

MGI:97011
NCBI Gene: 17395
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:164782700-164797770 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 85.27 cM, cytoband H1-H2
Mapping Data

8 experiments

SNPs within 2kb

505 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97011	protein coding gene	Chr2:164782246-164797770 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026883	protein coding gene	Chr2:170459606-170477486 (+)
A/J	MGP_AJ_G0026850	protein coding gene	Chr2:163480219-163496348 (+)
AKR/J	MGP_AKRJ_G0026821	protein coding gene	Chr2:168362180-168377272 (+)
BALB/cJ	MGP_BALBcJ_G0026859	protein coding gene	Chr2:163846832-163861927 (+)
C3H/HeJ	MGP_C3HHeJ_G0026601	protein coding gene	Chr2:168707803-168723495 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027306	protein coding gene	Chr2:175394242-175411062 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024677	protein coding gene	Chr2:156889473-156904927 (+)
CAST/EiJ	MGP_CASTEiJ_G0026059	protein coding gene	Chr2:169124522-169139621 (+)
CBA/J	MGP_CBAJ_G0026578	protein coding gene	Chr2:181758074-181776385 (+)
DBA/2J	MGP_DBA2J_G0026716	protein coding gene	Chr2:162646631-162662267 (+)
FVB/NJ	MGP_FVBNJ_G0026682	protein coding gene	Chr2:161071839-161086907 (+)
LP/J	MGP_LPJ_G0026818	protein coding gene	Chr2:170513968-170529015 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026701	protein coding gene	Chr2:185302214-185318058 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027363	protein coding gene	Chr2:168247973-168263028 (+)
PWK/PhJ	MGP_PWKPhJ_G0025796	protein coding gene	Chr2:162250546-162265661 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025597	protein coding gene	Chr2:167151579-167169440 (+)
WSB/EiJ	MGP_WSBEiJ_G0026132	protein coding gene	Chr2:169129635-169148710 (+)

Human Ortholog

MMP9, matrix metallopeptidase 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MMP9, matrix metallopeptidase 9
Synonyms

CLG4B, GELB, MANDP2, MMP-9
Links

HGNC:7176

NCBI Gene ID: 4318

neXtProt AC: NX_P14780

UniProt: P14780
Chr Location

20q13.12; chr20:46008908-46016561 (+) GRCh38

MGI Vertebrate Homology

Mmp9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MMP9
Gene Tree

Mmp9

Diseases

30 with human MMP9 associations

				Human Disease	Mouse Models
				angle-closure glaucoma IDs angle-closure glaucoma DOID:13550 MESH:D015812 NCI:C34639 UMLS_CUI:C0017605
				anodontia IDs anodontia DOID:13714 ICD10CM:K00.0 ICD9CM:520.0 MESH:D000848 NCI:C172328 OMIM:206780 UMLS_CUI:C0399352
				arteriosclerosis IDs arteriosclerosis DOID:2349 ICD10CM:I70 MESH:D001161 NCI:C34398 UMLS_CUI:C0003850
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				autism spectrum disorder IDs autism spectrum disorder DOID:0060041 MESH:D000067877
				bacterial meningitis IDs bacterial meningitis DOID:9470 ICD10CM:G00 ICD9CM:320 ICD9CM:320.9 MESH:D016920 NCI:C118297 UMLS_CUI:C0085437
				carotid artery disease IDs carotid artery disease DOID:3407 MESH:D002340 NCI:C84476 UMLS_CUI:C0007273
				chronic obstructive pulmonary disease IDs chronic obstructive pulmonary disease DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 UMLS_CUI:C0024117
				chronic ulcer of skin IDs chronic ulcer of skin DOID:8549 DOID:8548 DOID:8733 ICD10CM:L98.4 ICD9CM:707 UMLS_CUI:C0157738
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				diabetic retinopathy IDs diabetic retinopathy DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
				Down syndrome IDs Down syndrome DOID:14250 ICD10CM:Q90 ICD9CM:758.0 MESH:D004314 NCI:C2993 OMIM:190685 ORDO:870 UMLS_CUI:C0013080
				glioblastoma IDs glioblastoma DOID:3068 DOID:3075 DOID:3080 MESH:D005909 NCI:C129295 NCI:C39750 NCI:C9094 UMLS_CUI:C0017636 UMLS_CUI:C0278878 UMLS_CUI:C1514422
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				interstitial lung disease IDs interstitial lung disease DOID:3082 ICD10CM:J84.9 MESH:D017563 NCI:C164315 OMIM:PS619611 UMLS_CUI:C0206062
				intracranial aneurysm IDs intracranial aneurysm DOID:10941 EFO:0003870 MESH:D002532 NCI:C34458 UMLS_CUI:C0007766
				multiple sclerosis IDs multiple sclerosis DOID:2377 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 UMLS_CUI:C0026769
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				obstructive sleep apnea IDs obstructive sleep apnea DOID:0050848 ICD10CM:G47.33 ICD9CM:327.23 ICD9CM:780.57 MESH:D020181 NCI:C116337 OMIM:107650 UMLS_CUI:C0520679
				pigmentation disease IDs pigmentation disease DOID:10123 ICD9CM:709.09 UMLS_CUI:C0375489
				pulmonary emphysema IDs pulmonary emphysema DOID:9675 ICD10CM:J43.8 ICD9CM:492.8 OMIM:130700 UMLS_CUI:C0029607
				pulmonary hypertension IDs pulmonary hypertension DOID:6432 ICD10CM:I27.20 MESH:D006976 NCI:C3120 UMLS_CUI:C0020542
				Sjogren's syndrome IDs Sjogren's syndrome DOID:12894 DOID:416 ICD10CM:M35.0 ICD9CM:710.2 MESH:D012859 NCI:C26883 NCI:C70647 OMIM:270150 UMLS_CUI:C0086981 UMLS_CUI:C1527336
				skin melanoma IDs skin melanoma DOID:8923 DOID:0050609 DOID:10043 DOID:10046 DOID:10051 DOID:10052 DOID:10055 DOID:8922 ICD10CM:C43.9 ICD9CM:172 ICD9CM:172.0 ICD9CM:172.2 ICD9CM:172.4 ICD9CM:172.5 ICD9CM:172.9 MESH:C562393 NCI:C3510 OMIM:608035 OMIM:612263 UMLS_CUI:C0151779
				systemic scleroderma IDs systemic scleroderma DOID:418 EFO:0000717 ICD10CM:M34.0 ICD9CM_2006:710.1 ICD9CM:710.1 MESH:D012595 NCI:C72070 OMIM:181750 UMLS_CUI:C0036421
				temporal arteritis IDs temporal arteritis DOID:13375 ICD9CM:446.5 MESH:D013700 NCI:C35065 OMIM:187360 ORDO:397 UMLS_CUI:C0039483
				thoracic aortic aneurysm IDs thoracic aortic aneurysm DOID:14004 EFO:0004282 MESH:D017545 NCI:C27001 OMIM:132900 OMIM:607086 OMIM:607087 OMIM:611788 OMIM:613780 OMIM:615436 ORDO:91387 UMLS_CUI:C0162872
				thrombosis IDs thrombosis DOID:0060903 MESH:D013927
				varicose veins IDs varicose veins DOID:799 ICD10CM:I83.90 MESH:D014648 NCI:C35114 OMIM:192200 UMLS_CUI:C0042345
				ventricular septal defect IDs ventricular septal defect DOID:1657 ICD10CM:Q21.0 ICD9CM:745.4 MESH:D006345 NCI:C84506 OMIM:614429 OMIM:614431 OMIM:614432 ORDO:1480 UMLS_CUI:C0018818

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

97 phenotypes from 5 alleles in 20 genetic backgrounds
42 phenotypes from multigenic genotypes
322 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

5
Gene trapped

2
Targeted

9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Null mutants have short long bones with compensatory growth via delayed ossification and apoptosis of hypertrophic chondroctyes. Mutants are protected against ischemic brain injury, damage caused by myocardial infarction, and allergic airway inflammation.

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All GO Annotations

72
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1193
Tissues

229
cDNA Data

31
Literature Summary

207

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MMP9

Xenbase mmp9, mmp9.2

ZFIN mmp9

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All Sequences

51
RefSeq

4
UniProt

5
CCDS

CCDS17066.1

Ensembl

ENSMUSG00000017737 (Evidence)
NCBI Gene

17395

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017737	Ensembl Gene Model \| MGI Sequence Detail	15071	C57BL/6J	± kb
transcript	ENSMUST00000017881	Ensembl \| MGI Sequence Detail	3175	Not Applicable
polypeptide	ENSMUSP00000017881	Ensembl \| MGI Sequence Detail	730	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010491 matrix metalloproteinase-9

(term hierarchy)
EC

3.4.24.35
InterPro Domains

IPR000562 Fibronectin type II domain

IPR036943 Fibronectin type II domain superfamily

IPR018486 Hemopexin, conserved site

IPR000585 Hemopexin-like domain

IPR036375 Hemopexin-like domain superfamily

IPR018487 Hemopexin-like repeats

IPR013806 Kringle-like fold

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR021190 Peptidase M10A

IPR033739 Peptidase M10A, catalytic domain

IPR021158 Peptidase M10A, cysteine switch, zinc binding site

IPR001818 Peptidase M10, metallopeptidase

IPR006026 Peptidase, metallopeptidase

IPR036365 PGBD-like superfamily

IPR006970 PT repeat
GlyGen

P41245 3 sites

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All nucleic 71

Genomic 2

cDNA 33

Primer pair 26

Other 10

Microarray probesets 6

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MGD-MRK-12281, MGD-MRK-2014, MGI:2139414

Summaries

All 750

Developmental Gene Expression 207

Diseases 1

Gene Ontology 16

Phenotypes 322
Earliest

J:3961 Tanaka H, et al., Molecular cloning and expression of the mouse 105-kDa gelatinase cDNA. Biochem Biophys Res Commun. 1993 Feb 15;190(3):732-40
Latest

J:346910 Ayyangar U, et al., Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134

TSS for Mmp9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21687	Chr2:164782662-164782685 (+)	-26 bp
Tssr21688	Chr2:164788981-164788995 (+)	6,288 bp
Tssr21689	Chr2:164789661-164789668 (+)	6,965 bp
Tssr21690	Chr2:164790151-164790165 (+)	7,458 bp
Tssr21691	Chr2:164793070-164793081 (+)	10,376 bp
Tssr21692	Chr2:164793130-164793141 (+)	10,436 bp
Tssr21693	Chr2:164794343-164794354 (+)	11,649 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24