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Ndst2 Gene Detail
Summary
  • Symbol
    Ndst2
  • Name
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
  • Synonyms
    glucosaminyl N-deacetylase/N-sulphotransferase-2, [Heparan sulfate]-glucosamine N-sulfotransferase, Mndns
  • Feature Type
    protein coding gene
  • IDs
    MGI:97040
    NCBI Gene: 17423
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20773798-20784630 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97040
 protein coding gene Chr14:20773798-20784638 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021046
 protein coding gene Chr14:13490192-13500083 (-)
A/J MGP_AJ_G0020995
 protein coding gene Chr14:13179837-13190501 (-)
AKR/J MGP_AKRJ_G0020972
 protein coding gene Chr14:13705617-13717037 (-)
BALB/cJ MGP_BALBcJ_G0020998
 protein coding gene Chr14:13283783-13295688 (-)
C3H/HeJ MGP_C3HHeJ_G0020782
 protein coding gene Chr14:13644955-13655538 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021431
 protein coding gene Chr14:13991475-14002051 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018999
 protein coding gene Chr14:13496360-13503056 (-)
CAST/EiJ MGP_CASTEiJ_G0020306
 protein coding gene Chr14:13409763-13420359 (-)
CBA/J MGP_CBAJ_G0020748
 protein coding gene Chr14:14700534-14713585 (-)
DBA/2J MGP_DBA2J_G0020871
 protein coding gene Chr14:13004321-13014896 (-)
FVB/NJ MGP_FVBNJ_G0020854
 protein coding gene Chr14:12897641-12907992 (-)
LP/J MGP_LPJ_G0020947
 protein coding gene Chr14:13718180-13728761 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020880
 protein coding gene Chr14:14478899-14489725 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021464
 protein coding gene Chr14:13497436-13508017 (-)
PWK/PhJ MGP_PWKPhJ_G0020055
 protein coding gene Chr14:12574648-12585648 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019877
 protein coding gene Chr14:13292095-13302608 (-)
WSB/EiJ MGP_WSBEiJ_G0020362
 protein coding gene Chr14:13479934-13490776 (-)



Homology
more
  • Human Ortholog
    NDST2, N-deacetylase and N-sulfotransferase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDST2, N-deacetylase and N-sulfotransferase 2
  • Synonyms
    HSST2, N-HSST 2, NST2
  • Links
    NCBI Gene ID: 8509
    neXtProt AC: NX_P52849
    UniProt: P52849

  • Chr Location
    10q22.2; chr10:73801911-73811820 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozugous for a null allele exhibit reduced mast cell numbers, histamine storage, protease storage and degranulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    122
  • cDNA Data
    50
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039308 Ensembl Gene Model | MGI Sequence Detail 10833 C57BL/6J ±  kb
    transcript ENSMUST00000223679 Ensembl | MGI Sequence Detail 3907 Not Applicable  
    polypeptide ENSMUSP00000153036 Ensembl | MGI Sequence Detail 883 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 4
      cDNA 50
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12336
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 13
      Gene Ontology 15
      Phenotypes 31
    • Earliest
      J:17539 Eriksson I, et al., cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin. J Biol Chem. 1994 Apr 8;269(14):10438-43
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory