Map4 Gene Detail

Summary

• Symbol
  Map4
• Name
  microtubule-associated protein 4
• Synonyms
  MAP 4, Mtap4

• Feature Type
  protein coding gene
• IDs
  MGI:97178
  NCBI Gene: 17758
• Alliance
  gene page
• Transcription Start Sites
  63 TSS

Location &
Maps

• Sequence Map
  Chr9:109760528-109913023 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 59.83 cM
• Mapping Data
  8 experiments

Strain
Comparison

• SNPs within 2kb
  3500 from dbSNP Build 142
• Strain Annotations
  18
• PCR
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97178	protein coding gene	Chr9:109758909-109913023 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035340	protein coding gene	Chr9:112041305-112214613 (+)
A/J	MGP_AJ_G0035321	protein coding gene	Chr9:107982197-108137756 (+)
AKR/J	MGP_AKRJ_G0035252	protein coding gene	Chr9:110657710-110820216 (+)
BALB/cJ	MGP_BALBcJ_G0035316	protein coding gene	Chr9:107722917-107880485 (+)
C3H/HeJ	MGP_C3HHeJ_G0035024	protein coding gene	Chr9:111127216-111308173 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035838	protein coding gene	Chr9:115082678-115258050 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032724	protein coding gene	Chr9:105211468-105363284 (+)
CAST/EiJ	MGP_CASTEiJ_G0034330	protein coding gene	Chr9:110943185-111105277 (+)
CBA/J	MGP_CBAJ_G0034991	protein coding gene	Chr9:119372643-119540561 (+)
DBA/2J	MGP_DBA2J_G0035150	protein coding gene	Chr9:107442711-107600307 (+)
FVB/NJ	MGP_FVBNJ_G0035097	protein coding gene	Chr9:106271791-106427448 (+)
LP/J	MGP_LPJ_G0035229	protein coding gene	Chr9:112347208-112508037 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035137	protein coding gene	Chr9:120734009-120909997 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035858	protein coding gene	Chr9:110971377-111135690 (+)
PWK/PhJ	MGP_PWKPhJ_G0034037	protein coding gene	Chr9:107674885-107837247 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033872	protein coding gene	Chr9:111055885-111217286 (+)
WSB/EiJ	MGP_WSBEiJ_G0034451	protein coding gene	Chr9:110853005-111016063 (+)

Homology

• Human Ortholog
  MAP4, microtubule associated protein 4

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MAP4, microtubule associated protein 4
  
• Links
  HGNC:6862

  NCBI Gene ID: 4134

  neXtProt AC: NX_P27816

  UniProt: P27816

  
  
• Chr Location
  3p21.31; chr3:47850690-48089272 (-)  GRCh38

---

• MGI Vertebrate Homology
  Map4 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: MAP4
• Gene Tree
  Map4
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  12 phenotype references
  

• All Mutations and Alleles
  190
• Endonuclease-mediated
  3
• Gene trapped
  187
• Incidental Mutations
  APF
• Find Mice (IMSR)
  231 strains or lines available

Mice homozygous for a gene trapped allele are viable and do not display any overt phenotypic abnormalities.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  29
• GO References
  9

Expression

• Assay Results
  751
• Tissues
  26
• cDNA Data
  30
• Literature Summary
  6

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase map4

Sequences &
Gene Models

• All Sequences
  200
• RefSeq
  106
• UniProt
  13
• CCDS
  CCDS57703.1, CCDS57704.1, CCDS81082.1, CCDS81083.1

• Ensembl
  ENSMUSG00000032479 (Evidence)
• NCBI Gene
  17758

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000032479	Ensembl Gene Model | MGI Sequence Detail	152496	C57BL/6J
transcript	ENSMUST00000163190	Ensembl | MGI Sequence Detail	4322	Not Applicable
polypeptide	ENSMUSP00000143171	Ensembl | MGI Sequence Detail	1441	Not Applicable

Protein
Information

• UniProt
  13 Sequences
• Protein Ontology
  PR:000010142 microtubule-associated protein 4
  (term hierarchy)
• InterPro Domains
  IPR027324 Microtubule associated protein MAP2/MAP4/Tau
  IPR001084 Microtubule associated protein, tubulin-binding repeat
• GlyGen
  P27546 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 36

  cDNA 35

  Primer pair 1

  
  

  Microarray probesets 5

Other
Accession IDs

MGD-MRK-12582, MGD-MRK-12588, MGI:2142906

References

• Summaries
  All 56

  Developmental Gene Expression 6

  Gene Ontology 9

  Phenotypes 12
• Earliest
  J:11537 West RR, et al., A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences. J Biol Chem. 1991 Nov 15;266(32):21886-96
• Latest
  J:358165 Lucas L, et al., Alternatively spliced MAP4 isoforms have key roles in maintaining microtubule organization and skeletal muscle function. iScience. 2024 Nov 15;27(11):111104

TSS for Map4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87263	Chr9:109760531-109760556 (+)	16 bp
Tssr87264	Chr9:109760560-109760583 (+)	44 bp
Tssr87265	Chr9:109760610-109760620 (+)	87 bp
Tssr87266	Chr9:109760643-109760646 (+)	117 bp
Tssr87267	Chr9:109760842-109760866 (+)	326 bp
Tssr87268	Chr9:109760877-109760903 (+)	362 bp
Tssr87269	Chr9:109760904-109760921 (+)	385 bp
Tssr87270	Chr9:109760931-109760953 (+)	414 bp
Tssr3018	Chr9:109760955-109760960 (+)	430 bp
Tssr87271	Chr9:109760962-109760983 (+)	445 bp
Tssr87272	Chr9:109766290-109766306 (+)	5,770 bp
Tssr87273	Chr9:109774983-109775002 (+)	14,465 bp
Tssr87274	Chr9:109775040-109775063 (+)	14,524 bp
Tssr87275	Chr9:109777345-109777349 (+)	16,819 bp
Tssr87276	Chr9:109787668-109787673 (+)	27,143 bp
Tssr87280	Chr9:109828831-109828881 (+)	68,328 bp
Tssr87281	Chr9:109832244-109832260 (+)	71,724 bp
Tssr87282	Chr9:109832511-109832516 (+)	71,986 bp
Tssr87283	Chr9:109832706-109832710 (+)	72,180 bp
Tssr87284	Chr9:109832878-109832892 (+)	72,357 bp
Tssr87285	Chr9:109838626-109838633 (+)	78,102 bp
Tssr87286	Chr9:109839532-109839563 (+)	79,020 bp
Tssr87287	Chr9:109856768-109856787 (+)	96,250 bp
Tssr87288	Chr9:109856810-109856821 (+)	96,288 bp
Tssr87289	Chr9:109861194-109861207 (+)	100,673 bp
Tssr87290	Chr9:109861211-109861237 (+)	100,696 bp
Tssr87291	Chr9:109861244-109861261 (+)	100,725 bp
Tssr87292	Chr9:109861264-109861276 (+)	100,742 bp
Tssr87293	Chr9:109863448-109863482 (+)	102,937 bp
Tssr87294	Chr9:109863499-109863594 (+)	103,019 bp
Tssr87295	Chr9:109863615-109863633 (+)	103,096 bp
Tssr87296	Chr9:109863648-109863665 (+)	103,129 bp
Tssr87297	Chr9:109863666-109863686 (+)	103,148 bp
Tssr87298	Chr9:109863689-109863716 (+)	103,175 bp
Tssr87299	Chr9:109863734-109863747 (+)	103,213 bp
Tssr87300	Chr9:109863754-109863769 (+)	103,234 bp
Tssr87301	Chr9:109863789-109863809 (+)	103,271 bp
Tssr87302	Chr9:109863843-109863859 (+)	103,323 bp
Tssr87303	Chr9:109863862-109863875 (+)	103,341 bp
Tssr87304	Chr9:109863903-109863915 (+)	103,381 bp
Tssr87305	Chr9:109864006-109864023 (+)	103,487 bp
Tssr87306	Chr9:109864024-109864036 (+)	103,502 bp
Tssr87307	Chr9:109864297-109864309 (+)	103,775 bp
Tssr87308	Chr9:109864384-109864417 (+)	103,873 bp
Tssr87309	Chr9:109864438-109864448 (+)	103,915 bp
Tssr87310	Chr9:109865877-109865893 (+)	105,357 bp
Tssr87311	Chr9:109874500-109874505 (+)	113,975 bp
Tssr87312	Chr9:109881064-109881078 (+)	120,543 bp
Tssr87313	Chr9:109881084-109881179 (+)	120,604 bp
Tssr87314	Chr9:109881193-109881204 (+)	120,671 bp
Tssr87315	Chr9:109882374-109882391 (+)	121,855 bp
Tssr87316	Chr9:109884208-109884212 (+)	123,682 bp
Tssr87317	Chr9:109887877-109887883 (+)	127,352 bp
Tssr87318	Chr9:109891629-109891659 (+)	131,116 bp
Tssr87319	Chr9:109891676-109891688 (+)	131,154 bp
Tssr87320	Chr9:109891696-109891739 (+)	131,190 bp
Tssr87321	Chr9:109891859-109891871 (+)	131,337 bp
Tssr87322	Chr9:109891880-109891887 (+)	131,356 bp
Tssr87323	Chr9:109891900-109891919 (+)	131,382 bp
Tssr87324	Chr9:109892080-109892168 (+)	131,596 bp
Tssr87325	Chr9:109893421-109893435 (+)	132,900 bp
Tssr87326	Chr9:109893476-109893486 (+)	132,953 bp
Tssr87327	Chr9:109911704-109911719 (+)	151,184 bp