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Myc Gene Detail
Summary
  • Symbol
    Myc
  • Name
    myelocytomatosis oncogene
  • Synonyms
    bHLHe39, c-myc, Myc2, Niard, Nird
  • Feature Type
    protein coding gene
  • IDs
    MGI:97250
    NCBI Gene: 17869
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
  • Regulated by
    Rr357, Rr21, Rr356 ... (21 regulatory regions)
Location &
Maps
more
  • Sequence Map
    Chr15:61857240-61862223 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 26.19 cM, cytoband D2-D3
  • Mapping Data
    62 experiments
Strain
Comparison
more
  • SNPs within 2kb
    150 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    5
  • RFLP
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97250
 protein coding gene Chr15:61857190-61862223 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021890
 protein coding gene Chr15:61322402-61329671 (+)
A/J MGP_AJ_G0021849
 protein coding gene Chr15:58924253-58929729 (+)
AKR/J MGP_AKRJ_G0021831
 protein coding gene Chr15:60570722-60576766 (+)
BALB/cJ MGP_BALBcJ_G0021856
 protein coding gene Chr15:59115176-59121561 (+)
C3H/HeJ MGP_C3HHeJ_G0021630
 protein coding gene Chr15:60690555-60696279 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022295
 protein coding gene Chr15:63628035-63634726 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019833
 protein coding gene Chr15:56006532-56011549 (+)
CAST/EiJ MGP_CASTEiJ_G0021148
 protein coding gene Chr15:61348962-61353977 (+)
CBA/J MGP_CBAJ_G0021599
 protein coding gene Chr15:65902634-65910822 (+)
DBA/2J MGP_DBA2J_G0021723
 protein coding gene Chr15:58789607-58794889 (+)
FVB/NJ MGP_FVBNJ_G0021702
 protein coding gene Chr15:57840594-57845579 (+)
LP/J MGP_LPJ_G0021794
 protein coding gene Chr15:61217450-61222509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021725
 protein coding gene Chr15:70853292-70858309 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022318
 protein coding gene Chr15:60946801-60952650 (+)
PWK/PhJ MGP_PWKPhJ_G0020893
 protein coding gene Chr15:58861598-58866677 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020731
 protein coding gene Chr15:60740324-60745309 (+)
WSB/EiJ MGP_WSBEiJ_G0021204
 protein coding gene Chr15:60981351-60986384 (+)



Homology
more
  • Human Ortholog
    MYC, MYC proto-oncogene, bHLH transcription factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYC, MYC proto-oncogene, bHLH transcription factor
  • Synonyms
    bHLHe39, c-Myc, MRTL, MYCC
  • Links
    NCBI Gene ID: 4609
    neXtProt AC: NX_P01106
    UniProt: P01106

  • Chr Location
    8q24.21; chr8:127735434-127742951 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with Myc mouse models; 9 with human MYC associations

Human Disease Mouse Models
      
IDs
 View 7 models
IDs
 View 4 models
      
IDs
 View 1 model
IDs
 View 8 models
IDs
 View 3 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    18 with disease annotations
  • References
    22 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    199 phenotypes from 42 alleles in 39 genetic backgrounds
    143 phenotypes from multigenic genotypes
    2 images
    798 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations affect growth and development of heart, pericardium, neural tube, vasculogenesis and erythropoeisis. Homozygous null mutants die by embryonic day 10.5. Heterozygotes have reduced body size and multiorgan hypoplasia; females have small litters.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    229
  • GO References
    52
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1571
  • Tissues
    395
  • cDNA Data
    88
  • Literature Summary
    272
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022346 Ensembl Gene Model | MGI Sequence Detail 4984 C57BL/6J ±  kb
    transcript ENSMUST00000022971 Ensembl | MGI Sequence Detail 2338 Not Applicable  
    polypeptide ENSMUSP00000022971 Ensembl | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 192
      Genomic 46
      cDNA 89
      Primer pair 31
      Other 26

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12736, MGI:2146128
    References
    more
    • Summaries
      All 1587
      Developmental Gene Expression 272
      Diseases 22
      Gene Ontology 52
      Phenotypes 798
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:363240 Tamura T, et al., mTOR-mediated p62/SQSTM1 stabilization confers a robust survival mechanism for ovarian cancer. Cancer Lett. 2025 Apr 28;616:217565
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory