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Myl1 Gene Detail
Summary
  • Symbol
    Myl1
  • Name
    myosin, light polypeptide 1
  • Synonyms
    MLC1f, MLC3f, Mylf
  • Feature Type
    protein coding gene
  • IDs
    MGI:97269
    NCBI Gene: 17901
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:66963454-66984563 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 33.71 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97269
 protein coding gene Chr1:66963454-66987091 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016117
 protein coding gene Chr1:67195268-67216722 (-)
A/J MGP_AJ_G0016100
 protein coding gene Chr1:64815445-64836244 (-)
AKR/J MGP_AKRJ_G0016057
 protein coding gene Chr1:66673247-66694177 (-)
BALB/cJ MGP_BALBcJ_G0016055
 protein coding gene Chr1:64894087-64916966 (-)
C3H/HeJ MGP_C3HHeJ_G0015886
 protein coding gene Chr1:66916767-66940910 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016508
 protein coding gene Chr1:69786132-69807600 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014229
 protein coding gene Chr1:60741240-60761893 (-)
CAST/EiJ MGP_CASTEiJ_G0015470
 protein coding gene Chr1:66182671-66206688 (-)
CBA/J MGP_CBAJ_G0015859
 protein coding gene Chr1:72055444-72081749 (-)
DBA/2J MGP_DBA2J_G0015960
 protein coding gene Chr1:64208432-64234235 (-)
FVB/NJ MGP_FVBNJ_G0015963
 protein coding gene Chr1:63459099-63483946 (-)
LP/J MGP_LPJ_G0016032
 protein coding gene Chr1:68151148-68174239 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015983
 protein coding gene Chr1:75020771-75046090 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016555
 protein coding gene Chr1:66624450-66650377 (-)
PWK/PhJ MGP_PWKPhJ_G0015257
 protein coding gene Chr1:63605429-63627081 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015036
 protein coding gene Chr1:66089644-66112046 (-)
WSB/EiJ MGP_WSBEiJ_G0015532
 protein coding gene Chr1:66349485-66373045 (-)



Homology
more
  • Human Ortholog
    MYL1, myosin light chain 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYL1, myosin light chain 1
  • Synonyms
    CMYO14, CMYP14, MLC-1, MLC1, MLC1/3, MLC1F, MLC3F, MYOFTA
  • Links
    NCBI Gene ID: 4632
    neXtProt AC: NX_P05976
    UniProt: P05976

  • Chr Location
    2q34; chr2:210290150-210315174 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MYL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    65 phenotypes from multigenic genotypes
    2 images
    137 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit developmental delay, fail to form mesoderm, and die by embryonic day 8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1096
  • Tissues
    129
  • cDNA Data
    163
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061816 Ensembl Gene Model | MGI Sequence Detail 21110 C57BL/6J ±  kb
    transcript ENSMUST00000027151 Ensembl | MGI Sequence Detail 1082 Not Applicable  
    polypeptide ENSMUSP00000027151 Ensembl | MGI Sequence Detail 188 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 186
      Genomic 12
      cDNA 164
      Primer pair 8
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12767
    References
    more
    • Summaries
      All 225
      Developmental Gene Expression 35
      Diseases 1
      Gene Ontology 7
      Phenotypes 137
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:350917 Vanhoutte D, et al., Thbs1 regulates skeletal muscle mass in a TGFbeta-Smad2/3-ATF4-dependent manner. Cell Rep. 2024 May 28;43(5):114149
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory