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Ncam2 Gene Detail
Summary
  • Symbol
    Ncam2
  • Name
    neural cell adhesion molecule 2
  • Synonyms
    Ncam-2, Ocam, R4B12 antigen, RNCAM
  • Feature Type
    protein coding gene
  • IDs
    MGI:97282
    NCBI Gene: 17968
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:80997585-81423716 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 45.89 cM, cytoband C1-3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14363 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97282
 protein coding gene Chr16:80997501-81425549 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022966
 protein coding gene Chr16:81562421-82057882 (+)
A/J MGP_AJ_G0022934
 protein coding gene Chr16:77892856-78321252 (+)
AKR/J MGP_AKRJ_G0022904
 protein coding gene Chr16:80197328-80639546 (+)
BALB/cJ MGP_BALBcJ_G0022936
 protein coding gene Chr16:78287993-78731772 (+)
C3H/HeJ MGP_C3HHeJ_G0022698
 protein coding gene Chr16:80693289-81152137 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023383
 protein coding gene Chr16:84197744-84678312 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020887
 protein coding gene Chr16:76126254-76552479 (+)
CAST/EiJ MGP_CASTEiJ_G0022220
 protein coding gene Chr16:81179384-81642934 (+)
CBA/J MGP_CBAJ_G0022667
 protein coding gene Chr16:87749140-88255435 (+)
DBA/2J MGP_DBA2J_G0022801
 protein coding gene Chr16:77735846-78179022 (+)
FVB/NJ MGP_FVBNJ_G0022776
 protein coding gene Chr16:77022051-77447065 (+)
LP/J MGP_LPJ_G0022870
 protein coding gene Chr16:81258365-81714097 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022795
 protein coding gene Chr16:91387722-91999079 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023401
 protein coding gene Chr16:80568949-81038777 (+)
PWK/PhJ MGP_PWKPhJ_G0021962
 protein coding gene Chr16:77926354-78369317 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021792
 protein coding gene Chr16:80187324-80664072 (+)
WSB/EiJ MGP_WSBEiJ_G0022268
 protein coding gene Chr16:80806378-81273686 (+)



Homology
more
  • Human Ortholog
    NCAM2, neural cell adhesion molecule 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCAM2, neural cell adhesion molecule 2
  • Synonyms
    NCAM21
  • Links
    NCBI Gene ID: 4685
    neXtProt AC: NX_O15394
    UniProt: O15394

  • Chr Location
    21q21.1; chr21:20998409-21543329 (+)  GRCh38
Human Diseases
less
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    372 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A gene trap insertion into an intron of this gene results in no obvious phenotype. Mice homozygous for a knock-out allele exhibit exhibit increased proliferation rate and clonogenic frequency in spinal cord-derived neurospheres.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1002
  • Tissues
    154
  • cDNA Data
    23
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022762 Ensembl Gene Model | MGI Sequence Detail 426132 C57BL/6J ±  kb
    transcript ENSMUST00000067602 Ensembl | MGI Sequence Detail 6106 Not Applicable  
    polypeptide ENSMUSP00000063468 Ensembl | MGI Sequence Detail 837 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 23
      Primer pair 3
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12787, MGD-MRK-12788, MGI:1095738
    References
    more
    • Summaries
      All 433
      Developmental Gene Expression 32
      Diseases 7
      Gene Ontology 6
      Phenotypes 372
    • Earliest
      J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
    • Latest
      J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory