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Nedd9 Gene Detail
Summary
  • Symbol
    Nedd9
  • Name
    neural precursor cell expressed, developmentally down-regulated gene 9
  • Synonyms
    Cas-L, CasL, E230025G09Rik, HEF1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97302
    NCBI Gene: 18003
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:41463392-41640836 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 20.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4405 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97302
 protein coding gene Chr13:41463057-41640838 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020489
 protein coding gene Chr13:39799134-39983505 (-)
A/J MGP_AJ_G0020443
 protein coding gene Chr13:38469869-38649613 (-)
AKR/J MGP_AKRJ_G0020421
 protein coding gene Chr13:39513739-39698051 (-)
BALB/cJ MGP_BALBcJ_G0020439
 protein coding gene Chr13:38655029-38834554 (-)
C3H/HeJ MGP_C3HHeJ_G0020238
 protein coding gene Chr13:39393147-39575715 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020872
 protein coding gene Chr13:41059521-41249735 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018459
 protein coding gene Chr13:36602637-36782358 (-)
CAST/EiJ MGP_CASTEiJ_G0019753
 protein coding gene Chr13:39179022-39372390 (-)
CBA/J MGP_CBAJ_G0020199
 protein coding gene Chr13:42817746-43014646 (-)
DBA/2J MGP_DBA2J_G0020321
 protein coding gene Chr13:38039235-38216989 (-)
FVB/NJ MGP_FVBNJ_G0020300
 protein coding gene Chr13:37534610-37720032 (-)
LP/J MGP_LPJ_G0020396
 protein coding gene Chr13:40040759-40230365 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020329
 protein coding gene Chr13:42786161-42970613 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020915
 protein coding gene Chr13:39163809-39347018 (-)
PWK/PhJ MGP_PWKPhJ_G0019508
 protein coding gene Chr13:38121120-38301279 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019338
 protein coding gene Chr13:37798146-37987186 (-)
WSB/EiJ MGP_WSBEiJ_G0019815
 protein coding gene Chr13:39469926-39654131 (-)



Homology
more
  • Human Ortholog
    NEDD9, neural precursor cell expressed, developmentally down-regulated 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEDD9, neural precursor cell expressed, developmentally down-regulated 9
  • Synonyms
    CAS2, CAS-L, CASL, CASS2, HEF1
  • Links
    NCBI Gene ID: 4739
    neXtProt AC: NX_Q14511
    UniProt: Q14511

  • Chr Location
    6p24.2; chr6:11183298-11382348 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit impaired lymphocyte trafficking and a deficit of splenic marginal zone B cells. Mice homozygous for another null allele display impaired spatial learning and decreased hippocampal dendritic spine densities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1047
  • Tissues
    118
  • cDNA Data
    96
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18003 NCBI Gene Model | MGI Sequence Detail 177445 C57BL/6J ±  kb
    transcript NM_001111324 RefSeq | MGI Sequence Detail 4603 C57BL/6  
    polypeptide O35177 UniProt | EBI | MGI Sequence Detail 833 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      cDNA 96
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12815, MGI:2442508
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 18
      Gene Ontology 15
      Phenotypes 22
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:339438 Wong W, et al., An adhesion signaling axis involving Dystroglycan, beta1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold. PLoS Biol. 2023 Aug;21(8):e3002212
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory