About   Help   FAQ
Nek1 Gene Detail
Summary
  • Symbol
    Nek1
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 1
  • Synonyms
    D8Ertd790e, kat, kidney, anemia and testis
  • Feature Type
    protein coding gene
  • IDs
    MGI:97303
    NCBI Gene: 18004
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:61446229-61584380 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 30.91 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2788 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97303
 protein coding gene Chr8:61446184-61584383 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033633
 protein coding gene Chr8:60877589-61027810 (+)
A/J MGP_AJ_G0033615
 protein coding gene Chr8:58293340-58429460 (+)
AKR/J MGP_AKRJ_G0033540
 protein coding gene Chr8:59969525-60109499 (+)
BALB/cJ MGP_BALBcJ_G0033611
 protein coding gene Chr8:58551254-58683523 (+)
C3H/HeJ MGP_C3HHeJ_G0033321
 protein coding gene Chr8:60635733-60774385 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034128
 protein coding gene Chr8:63207428-63350788 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031076
 protein coding gene Chr8:53548235-53682849 (+)
CAST/EiJ MGP_CASTEiJ_G0032646
 protein coding gene Chr8:60061063-60198773 (+)
CBA/J MGP_CBAJ_G0033299
 protein coding gene Chr8:65490756-65644549 (+)
DBA/2J MGP_DBA2J_G0033453
 protein coding gene Chr8:58048595-58188031 (+)
FVB/NJ MGP_FVBNJ_G0033394
 protein coding gene Chr8:57363026-57491024 (+)
LP/J MGP_LPJ_G0033541
 protein coding gene Chr8:60851043-61003318 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033438
 protein coding gene Chr8:67595015-67754979 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034146
 protein coding gene Chr8:60221011-60352927 (+)
PWK/PhJ MGP_PWKPhJ_G0032355
 protein coding gene Chr8:57357117-57490998 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032191
 protein coding gene Chr8:59186408-59331113 (+)
WSB/EiJ MGP_WSBEiJ_G0032763
 protein coding gene Chr8:60549114-60690291 (+)



Homology
more
  • Human Ortholog
    NEK1, NIMA related kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEK1, NIMA related kinase 1
  • Synonyms
    ALS24, NY-REN-55, OFD2, SRPS2, SRPS2A, SRTD6
  • Links
    NCBI Gene ID: 4750
    neXtProt AC: NX_Q96PY6
    UniProt: Q96PY6

  • Chr Location
    4q33; chr4:169369704-169612632 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nek1 mouse models; 4 with human NEK1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 3 alleles in 6 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Spontaneous mutations of this gene result in pleiotropic effects that include facial dysmorphism, dwarfism, male sterility, anemia, cystic choroid plexus, a late-onset slowly progressive polycystic kidney disease, and premature death. Postnatal survival is sensitive to genetic background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    34
  • cDNA Data
    28
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031644 Ensembl Gene Model | MGI Sequence Detail 138152 C57BL/6J ±  kb
    transcript ENSMUST00000211672 Ensembl | MGI Sequence Detail 5109 Not Applicable  
    polypeptide ENSMUSP00000147809 Ensembl | MGI Sequence Detail 1275 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 29
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12816, MGD-MRK-38304, MGI:109259, MGI:1289217
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 12
      Phenotypes 24
    • Earliest
      J:2376 Letwin K, et al., A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J. 1992 Oct;11(10):3521-31
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory