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Nfkb1 Gene Detail
Summary
  • Symbol
    Nfkb1
  • Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
  • Synonyms
    NF-kappaB, NF kappaB1, NF-kappaB p50, nuclear factor kappaB p50, p50, p50/p105, p50 subunit of NF kappaB
  • Feature Type
    protein coding gene
  • IDs
    MGI:97312
    NCBI Gene: 18033
  • Alliance
    gene page
  • Transcription Start Sites
    45 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:135290416-135397308 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 62.82 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3139 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97312
 protein coding gene Chr3:135290416-135397422 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027909
 protein coding gene Chr3:138493487-138607219 (-)
A/J MGP_AJ_G0027867
 protein coding gene Chr3:133622891-133731332 (-)
AKR/J MGP_AKRJ_G0027832
 protein coding gene Chr3:137159469-137270960 (-)
BALB/cJ MGP_BALBcJ_G0027880
 protein coding gene Chr3:133472853-133581623 (-)
C3H/HeJ MGP_C3HHeJ_G0027609
 protein coding gene Chr3:137502859-137613325 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028323
 protein coding gene Chr3:143323708-143441258 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025661
 protein coding gene Chr3:128844668-128953853 (-)
CAST/EiJ MGP_CASTEiJ_G0027065
 protein coding gene Chr3:137205548-137339843 (-)
CBA/J MGP_CBAJ_G0027585
 protein coding gene Chr3:148159215-148278617 (-)
DBA/2J MGP_DBA2J_G0027725
 protein coding gene Chr3:132772808-132879913 (-)
FVB/NJ MGP_FVBNJ_G0027692
 protein coding gene Chr3:130264921-130372794 (-)
LP/J MGP_LPJ_G0027835
 protein coding gene Chr3:139918898-140031794 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027723
 protein coding gene Chr3:156283044-156394317 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028381
 protein coding gene Chr3:136691399-136805585 (-)
PWK/PhJ MGP_PWKPhJ_G0026789
 protein coding gene Chr3:132492940-132601887 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026615
 protein coding gene Chr3:134783065-134900746 (-)
WSB/EiJ MGP_WSBEiJ_G0027144
 protein coding gene Chr3:137488054-137600649 (-)



Homology
more
  • Human Ortholog
    NFKB1, nuclear factor kappa B subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFKB1, nuclear factor kappa B subunit 1
  • Synonyms
    CVID12, EBP-1, KBF1, NF-kappaB, NFkappaB, NF-kappa-B1, NF-kappabeta, NF-kB, NF-kB1, NFKB-p105, NFKB-p50
  • Links
    NCBI Gene ID: 4790
    neXtProt AC: NX_P19838
    UniProt: P19838

  • Chr Location
    4q24; chr4:102501330-102617302 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human NFKB1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    101 phenotypes from 11 alleles in 18 genetic backgrounds
    56 phenotypes from multigenic genotypes
    295 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have a decreased survivor rate, abnormal T cell development and decreased number of peripheral T cells, abnormal humoral responses with decreased immunoglobulin class switching, exhibit mild organ inflammation, and are susceptible toboth bacterial infections and hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    58
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    970
  • Tissues
    209
  • cDNA Data
    117
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028163 Ensembl Gene Model | MGI Sequence Detail 106893 C57BL/6J ±  kb
    transcript ENSMUST00000029812 Ensembl | MGI Sequence Detail 4117 Not Applicable  
    polypeptide ENSMUSP00000029812 Ensembl | MGI Sequence Detail 971 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 124
      cDNA 118
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12829
    References
    more
    • Summaries
      All 897
      Developmental Gene Expression 32
      Diseases 1
      Gene Ontology 58
      Phenotypes 295
    • Earliest
      J:25020 Ghosh S, et al., Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell. 1990 Sep 7;62(5):1019-29
    • Latest
      J:353685 Harada M, et al., Sustained activation of NF-kappaB through constitutively active IKKbeta leads to senescence bypass in murine dermal fibroblasts. Cell Cycle. 2024 Feb;23(3):308-327
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory