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Nfya
Gene Detail
Symbol

Name
ID
Nfya
nuclear transcription factor-Y alpha
MGI:97316
Synonyms
Cbf-b, Sez10
Feature Type
protein coding gene
Genetic Map
Chromosome 17
23.99 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr17:48386885-48409906 bp, - strand
From VEGA annotation of GRCm38

  23022 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32114  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Nfya

Human
homologs
Human Homolog NFYA, nuclear transcription factor Y, alpha
NCBI Gene ID 4800
neXtProt AC  NX_P23511
Human Synonyms  CBF-A, CBF-B, HAP2, NF-YA
Human Chr (Location)  6p21.3; chr6:41072968-41102407 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(111) : Gene trapped(107) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this locus impairs development and results in embryonic lethality.
 
Interactions
Nfya interacts with 333 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (64)    Tissues (64)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 56
RT-PCR 8
cDNA source data(116)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(123) Genomic(4) cDNA(116) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000035112 (Evidence)
Ensembl Gene ModelENSMUSG00000023994 (Evidence)
Entrez Gene18044 (Evidence)
UniGene4929
DFCITC1575982, TC1597000, TC1603975
DoTSDT.110580643, DT.491315, DT.94152315, DT.94184237
NIA Mouse Gene IndexU037898
Consensus CDS ProjectCCDS28867.1, CCDS50142.1
International Mouse Knockout Project StatusNfya
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035112 VEGA Gene Model | MGI Sequence Detail 23022 C57BL/6J ±  kb
transcript OTTMUST00000089324 VEGA | MGI Sequence Detail 3645 Not Applicable 
polypeptide OTTMUSP00000048807 VEGA | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(16) UniProt(9)
Polymorphisms
RFLP(2) : SNPs within 2kb(204 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018362 CCAAT-binding factor, conserved site
InterPro IPR001289 CCAAT-binding transcription factor, subunit B
Protein Ontology PR:000011188 nuclear transcription factor Y subunit alpha
References
(Earliest) J:10763 van Huijsduijnen RH, et al., Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits. EMBO J. 1990 Oct;9(10):3119-27
(Latest) J:210267 Yamanaka T, et al., NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization. Nat Commun. 2014;5:3354
All references(74)
Other
accession IDs
MGD-MRK-12835, MGI:2146744

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory