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Ngfr Gene Detail
Summary
  • Symbol
    Ngfr
  • Name
    nerve growth factor receptor (TNFR superfamily, member 16)
  • Synonyms
    LNGFR, p75, p75 neurotrophin receptor, p75NGFR, p75NTR, Tnfrsf16
  • Feature Type
    protein coding gene
  • IDs
    MGI:97323
    NCBI Gene: 18053
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:95459644-95478524 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    568 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97323
 protein coding gene Chr11:95459644-95478561 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018985
 protein coding gene Chr11:97773957-97792876 (-)
A/J MGP_AJ_G0018953
 protein coding gene Chr11:93835507-93854458 (-)
AKR/J MGP_AKRJ_G0018923
 protein coding gene Chr11:96734769-96753718 (-)
BALB/cJ MGP_BALBcJ_G0018926
 protein coding gene Chr11:94312015-94330875 (-)
C3H/HeJ MGP_C3HHeJ_G0018740
 protein coding gene Chr11:96860135-96879090 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019378
 protein coding gene Chr11:100842743-100861943 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017009
 protein coding gene Chr11:91316953-91335944 (-)
CAST/EiJ MGP_CASTEiJ_G0018294
 protein coding gene Chr11:97673160-97692003 (-)
CBA/J MGP_CBAJ_G0018711
 protein coding gene Chr11:104974527-104993458 (-)
DBA/2J MGP_DBA2J_G0018819
 protein coding gene Chr11:93405070-93424014 (-)
FVB/NJ MGP_FVBNJ_G0018808
 protein coding gene Chr11:92876783-92895637 (-)
LP/J MGP_LPJ_G0018889
 protein coding gene Chr11:98345400-98366175 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018835
 protein coding gene Chr11:104996532-105015397 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019418
 protein coding gene Chr11:97004007-97023270 (-)
PWK/PhJ MGP_PWKPhJ_G0018065
 protein coding gene Chr11:94337468-94362296 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017854
 protein coding gene Chr11:96697733-96716852 (-)
WSB/EiJ MGP_WSBEiJ_G0018343
 protein coding gene Chr11:96924667-96943613 (-)



Homology
more
  • Human Ortholog
    NGFR, nerve growth factor receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NGFR, nerve growth factor receptor
  • Synonyms
    CD271, Gp80-LNGFR, p75(NTR), p75NTR, TNFRSF16
  • Links
    NCBI Gene ID: 4804
    neXtProt AC: NX_P08138
    UniProt: P08138

  • Chr Location
    17q21.33; chr17:49495293-49515008 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human NGFR associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 6 alleles in 14 genetic backgrounds
    27 phenotypes from multigenic genotypes
    3 images
    257 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit increased perinatal lethality, skin abnormalities, growth retardation, reduced sensory nerve innervation, elevated pain threshold, ataxia, reduced sciatic nerve diameter, and blood vessel abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    110
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1600
  • Tissues
    387
  • cDNA Data
    34
  • Literature Summary
    347
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18053 NCBI Gene Model | MGI Sequence Detail 18881 C57BL/6J ±  kb
    transcript NM_033217 RefSeq | MGI Sequence Detail 3409 C57BL/6  
    polypeptide Q9Z0W1 UniProt | EBI | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000001405 tumor necrosis factor receptor superfamily member 16
      (term hierarchy)
    • InterPro Domains
      IPR000488 Death domain
      IPR011029 Death-like domain superfamily
      IPR052302 Neurotrophin receptor-related death domain-containing protein
      IPR001368 TNFR/NGFR cysteine-rich region
      IPR034046 Tumor necrosis factor receptor 16, N-terminal
      IPR041448 Tumor necrosis factor receptor member 16, transmembrane domain
      IPR022325 Tumour necrosis factor receptor 16
    • GlyGen
      Q9Z0W1 1 site
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 2
      cDNA 44
      Primer pair 12
      Other 12

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12842
    References
    more
    • Summaries
      All 704
      Developmental Gene Expression 347
      Gene Ontology 27
      Phenotypes 257
    • Earliest
      J:14649 Sutter A, et al., Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. J Biol Chem. 1979 Jul 10;254(13):5972-82
    • Latest
      J:357471 Pagella P, et al., An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation. Int J Oral Sci. 2024;16(1):60
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory