Nkx2-6 MGI Mouse Gene Detail - MGI:97351

Symbol

Nkx2-6
Name

NK2 homeobox 6
Synonyms

Nkx-2.6, Nkx2.6, tinman, Tix

Feature Type

protein coding gene
IDs

MGI:97351
NCBI Gene: 18092
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:69409251-69412967 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.01 cM
Mapping Data

5 experiments

SNPs within 2kb

229 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97351	protein coding gene	Chr14:69409251-69412989 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021514	protein coding gene	Chr14:63938640-63942400 (+)
A/J	MGP_AJ_G0021473	protein coding gene	Chr14:62425426-62429142 (+)
AKR/J	MGP_AKRJ_G0021449	protein coding gene	Chr14:64522019-64525735 (+)
BALB/cJ	MGP_BALBcJ_G0021479	protein coding gene	Chr14:62404553-62408265 (+)
C3H/HeJ	MGP_C3HHeJ_G0021256	protein coding gene	Chr14:64248676-64252392 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021918	protein coding gene	Chr14:66856209-66859913 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019458	protein coding gene	Chr14:60266564-60270289 (+)
CAST/EiJ	MGP_CASTEiJ_G0020773	protein coding gene	Chr14:60780063-60783819 (+)
CBA/J	MGP_CBAJ_G0021223	protein coding gene	Chr14:68941681-68945393 (+)
DBA/2J	MGP_DBA2J_G0021346	protein coding gene	Chr14:62025809-62029529 (+)
FVB/NJ	MGP_FVBNJ_G0021325	protein coding gene	Chr14:61443303-61446999 (+)
LP/J	MGP_LPJ_G0021421	protein coding gene	Chr14:65007024-65010784 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021354	protein coding gene	Chr14:67897964-67901686 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021941	protein coding gene	Chr14:63776079-63779783 (+)
PWK/PhJ	MGP_PWKPhJ_G0020517	protein coding gene	Chr14:58775977-58779730 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020350	protein coding gene	Chr14:59707307-59711117 (+)
WSB/EiJ	MGP_WSBEiJ_G0020826	protein coding gene	Chr14:64075257-64078959 (+)

Human Ortholog

NKX2-6, NK2 homeobox 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NKX2-6, NK2 homeobox 6
Synonyms

CSX2, CTHM, NKX2F, NKX4-2
Links

HGNC:32940

NCBI Gene ID: 137814

neXtProt AC: NX_A6NCS4

UniProt: A6NCS4
Chr Location

8p21.2; chr8:23701740-23706756 (-) GRCh38

MGI Vertebrate Homology

Nkx2-6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NKX2-6
Gene Tree

Nkx2-6

Diseases

2 with human NKX2-6 associations

				Human Disease	Mouse Models
				familial atrial fibrillation IDs familial atrial fibrillation DOID:0050650 OMIM:607554 OMIM:608583 OMIM:608988 OMIM:611493 OMIM:611494 OMIM:612201 OMIM:612240 OMIM:613055 OMIM:613980 OMIM:614022 OMIM:614049 OMIM:614050 OMIM:615377 OMIM:615378 OMIM:615770 OMIM:PS608583 ORDO:334
				ventricular septal defect IDs ventricular septal defect DOID:1657 ICD10CM:Q21.0 ICD9CM:745.4 MESH:D006345 NCI:C84506 OMIM:614429 OMIM:614431 OMIM:614432 ORDO:1480 UMLS_CUI:C0018818

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

1 involving Nkx2-6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null allele are viable and fertile and develop normally, with no anomalies detected in the caudal pharyngeal pouch derivatives, heart or gut.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

992
Tissues

219
cDNA Data

15
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NKX2-6

Xenbase nkx2-6

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All Sequences

43
RefSeq

4
UniProt

5
CCDS

CCDS56968.1

Ensembl

ENSMUSG00000044186 (Evidence)
NCBI Gene

18092

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044186	Ensembl Gene Model \| MGI Sequence Detail	3717	C57BL/6J	± kb
transcript	ENSMUST00000062437	Ensembl \| MGI Sequence Detail	1134	Not Applicable
polypeptide	ENSMUSP00000049898	Ensembl \| MGI Sequence Detail	289	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011246 homeobox protein Nkx-2.6

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR050394 Homeobox NK-like transcription regulators

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All nucleic 29

Genomic 3

cDNA 15

Primer pair 6

Other 5

Microarray probesets 5

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MGD-MRK-12893, MGI:2145773

Summaries

All 56

Developmental Gene Expression 17

Gene Ontology 8

Phenotypes 12
Earliest

J:15282 Lints TJ, et al., Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants [published erratum appears in Development 1993 Nov;119(3):969]. Development. 1993 Oct;119(2):419-31
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nkx2-6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126367	Chr14:69409388-69409413 (+)	150 bp
Tssr126368	Chr14:69409427-69409442 (+)	184 bp
Tssr126369	Chr14:69409457-69409462 (+)	209 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24