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Nodal Gene Detail
Summary
  • Symbol
    Nodal
  • Name
    nodal growth differentiation factor
  • Synonyms
    Tg.413d
  • Feature Type
    protein coding gene
  • IDs
    MGI:97359
    NCBI Gene: 18119
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61253751-61261117 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97359
 protein coding gene Chr10:61253751-61261117 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017279
 protein coding gene Chr10:60760072-60769748 (+)
A/J MGP_AJ_G0017257
 protein coding gene Chr10:58934760-58943529 (+)
AKR/J MGP_AKRJ_G0017217
 protein coding gene Chr10:60478680-60486890 (+)
BALB/cJ MGP_BALBcJ_G0017217
 protein coding gene Chr10:59021635-59029283 (+)
C3H/HeJ MGP_C3HHeJ_G0017040
 protein coding gene Chr10:60383690-60391021 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017675
 protein coding gene Chr10:62919200-62926380 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015366
 protein coding gene Chr10:55918813-55925684 (+)
CAST/EiJ MGP_CASTEiJ_G0016611
 protein coding gene Chr10:60375979-60383194 (+)
CBA/J MGP_CBAJ_G0017012
 protein coding gene Chr10:65280332-65288370 (+)
DBA/2J MGP_DBA2J_G0017117
 protein coding gene Chr10:58211080-58218975 (+)
FVB/NJ MGP_FVBNJ_G0017111
 protein coding gene Chr10:57466209-57475269 (+)
LP/J MGP_LPJ_G0017192
 protein coding gene Chr10:61158780-61166489 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017139
 protein coding gene Chr10:67597028-67604147 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017713
 protein coding gene Chr10:60290391-60307315 (+)
PWK/PhJ MGP_PWKPhJ_G0016394
 protein coding gene Chr10:58049743-58059581 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016176
 protein coding gene Chr10:59629936-59652014 (+)
WSB/EiJ MGP_WSBEiJ_G0016675
 protein coding gene Chr10:60215258-60224281 (+)



Homology
more
  • Human Ortholog
    NODAL, nodal growth differentiation factor
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NODAL, nodal growth differentiation factor
  • Synonyms
    HTX5
  • Links
    NCBI Gene ID: 4838
    neXtProt AC: NX_Q96S42
    UniProt: Q96S42

  • Chr Location
    10q22.1; chr10:70431936-70447951 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NODAL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    111 phenotypes from 15 alleles in 18 genetic backgrounds
    75 phenotypes from multigenic genotypes
    116 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants fail to form a primitive streak, show placental defects and die at gastrulation. Hypomorphic mutants are defective in anterior-posterior, anterior-midline, and left-right body patterning, resulting in multiple organ defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    116
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1529
  • Tissues
    108
  • cDNA Data
    9
  • Literature Summary
    262
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18119 NCBI Gene Model | MGI Sequence Detail 7367 C57BL/6J ±  kb
    transcript NM_013611 RefSeq | MGI Sequence Detail 2095 C57BL/6  
    polypeptide P43021 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 3
      cDNA 16
      Primer pair 17
      Other 48

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12907, MGD-MRK-15051, MGI:98714
    References
    more
    • Summaries
      All 377
      Developmental Gene Expression 262
      Diseases 1
      Gene Ontology 34
      Phenotypes 116
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:354455 Chen X, et al., SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development. Int J Biol Macromol. 2024 Aug;274(Pt 2):133294
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory