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Npr2 Gene Detail
Summary
  • Symbol
    Npr2
  • Name
    natriuretic peptide receptor 2
  • Synonyms
    cn, guanylyl cyclase-B, pwe
  • Feature Type
    protein coding gene
  • IDs
    MGI:97372
    NCBI Gene: 230103
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43631935-43651244 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    488 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97372
 protein coding gene Chr4:43629015-43651437 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028217
 protein coding gene Chr4:41765037-41784472 (+)
A/J MGP_AJ_G0028173
 protein coding gene Chr4:40274942-40295180 (+)
AKR/J MGP_AKRJ_G0028125
 protein coding gene Chr4:41188033-41207412 (+)
BALB/cJ MGP_BALBcJ_G0028193
 protein coding gene Chr4:40365905-40385335 (+)
C3H/HeJ MGP_C3HHeJ_G0027915
 protein coding gene Chr4:41825850-41845113 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028634
 protein coding gene Chr4:43325902-43345209 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025946
 protein coding gene Chr4:37723289-37742587 (+)
CAST/EiJ MGP_CASTEiJ_G0027355
 protein coding gene Chr4:41330768-41352008 (+)
CBA/J MGP_CBAJ_G0027881
 protein coding gene Chr4:44651879-44671293 (+)
DBA/2J MGP_DBA2J_G0028030
 protein coding gene Chr4:40186290-40205719 (+)
FVB/NJ MGP_FVBNJ_G0027997
 protein coding gene Chr4:39410579-39432212 (+)
LP/J MGP_LPJ_G0028129
 protein coding gene Chr4:41816603-41835920 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028021
 protein coding gene Chr4:47903289-47922581 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028670
 protein coding gene Chr4:41398740-41418057 (+)
PWK/PhJ MGP_PWKPhJ_G0027081
 protein coding gene Chr4:40221780-40241385 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026907
 protein coding gene Chr4:40965482-40984905 (+)
WSB/EiJ MGP_WSBEiJ_G0027435
 protein coding gene Chr4:41296416-41315802 (+)



Homology
more
  • Human Ortholog
    NPR2, natriuretic peptide receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPR2, natriuretic peptide receptor 2
  • Synonyms
    AMD1, AMDM, ANPb, ANPRB, ECDM, GC-B, GCB, GUC2B, GUCY2B, NPRB, NPRBi, SNSK
  • Links
    NCBI Gene ID: 4882
    neXtProt AC: NX_P20594
    UniProt: P20594

  • Chr Location
    9p13.3; chr9:35791003-35809732 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Npr2 mouse models; 3 with human NPR2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 3 models
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    115 phenotypes from 11 alleles in 14 genetic backgrounds
    20 phenotypes from multigenic genotypes
    9 images
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in skeletal abnormalities, malocclusion, and reduced viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    115
  • GO References
    32
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    115
  • cDNA Data
    32
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028469 Ensembl Gene Model | MGI Sequence Detail 19310 C57BL/6J ±  kb
    transcript ENSMUST00000030191 Ensembl | MGI Sequence Detail 3660 Not Applicable  
    polypeptide ENSMUSP00000030191 Ensembl | MGI Sequence Detail 1047 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000011378 atrial natriuretic peptide receptor 2
      (term hierarchy)
    • EC
      4.6.1.2
    • InterPro Domains
      IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
      IPR001170 Adenylyl cyclase class-4/guanylyl cyclase
      IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
      IPR052612 Atrial Natriuretic Peptide Clearance Receptor
      IPR050401 Cyclic nucleotide synthase
      IPR029787 Nucleotide cyclase
      IPR028082 Periplasmic binding protein-like I
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001828 Receptor, ligand binding region
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    • GlyGen
      Q6VVW5 7 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 34
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12926, MGD-MRK-2032, MGI:1933832, MGI:88430
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 15
      Diseases 6
      Gene Ontology 32
      Phenotypes 63
    • Earliest
      J:5088 Koniukhov BV, et al., Experimental study of the achondroplasia gene effects in the mouse. Acta Biol Acad Sci Hung. 1967;18(3):285-94
    • Latest
      J:349350 Egbert JR, et al., Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase. Biol Reprod. 2024 Jan 13;110(1):102-115
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory