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Ntf5 Gene Detail
Summary
  • Symbol
    Ntf5
  • Name
    neurotrophin 5
  • Synonyms
    2900040K06Rik, neurotrophin-4, NT-4, NT4, NT4/5, Ntf4, Ntf-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:97381
    NCBI Gene: 78405
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45063119-45066603 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97381
 protein coding gene Chr7:45063119-45066603 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032219
 protein coding gene Chr7:45669281-45673108 (+)
A/J MGP_AJ_G0032198
 protein coding gene Chr7:44800372-44803857 (+)
AKR/J MGP_AKRJ_G0032134
 protein coding gene Chr7:46041792-46046748 (+)
BALB/cJ MGP_BALBcJ_G0032210
 protein coding gene Chr7:44789360-44792842 (+)
C3H/HeJ MGP_C3HHeJ_G0031926
 protein coding gene Chr7:46520280-46524851 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032702
 protein coding gene Chr7:47937499-47943626 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029716
 protein coding gene Chr7:47351208-47354686 (+)
CAST/EiJ MGP_CASTEiJ_G0031254
 protein coding gene Chr7:37932632-37936109 (+)
CBA/J MGP_CBAJ_G0031890
 protein coding gene Chr7:49521354-49524787 (+)
DBA/2J MGP_DBA2J_G0032048
 protein coding gene Chr7:44462924-44466318 (+)
FVB/NJ MGP_FVBNJ_G0031999
 protein coding gene Chr7:44248470-44251767 (+)
LP/J MGP_LPJ_G0032126
 protein coding gene Chr7:46369127-46372599 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032036
 protein coding gene Chr7:48222368-48225845 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032718
 protein coding gene Chr7:45255079-45258584 (+)
PWK/PhJ MGP_PWKPhJ_G0030977
 protein coding gene Chr7:37837230-37840772 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030814
 protein coding gene Chr7:33264765-33268242 (+)
WSB/EiJ MGP_WSBEiJ_G0031371
 protein coding gene Chr7:45747439-45750901 (+)



Homology
more
  • Human Ortholog
    NTF4, neurotrophin 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTF4, neurotrophin 4
  • Synonyms
    GLC10, GLC1O, NT-4, NT4, NT-4/5, NT-5, NT5, NTF5
  • Links
    NCBI Gene ID: 4909
    neXtProt AC: NX_P34130
    UniProt: P34130

  • Chr Location
    19q13.33; chr19:49058284-49065076 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit sensory neuron deficits. One nullizygous mutation causes loss of BDNF-dependent neural crest-derived sensory neurons and impaired coordination, while another leads to reduced neuron apoptosis, thick skin, and altered hair cycle control.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    29
  • cDNA Data
    10
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 78405 NCBI Gene Model | MGI Sequence Detail 3485 C57BL/6J ±  kb
    transcript NM_198190 RefSeq | MGI Sequence Detail 2027 Not Specified  
    polypeptide Q80VU4 UniProt | EBI | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 10
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12938, MGD-MRK-12940, MGD-MRK-24018, MGI:103152, MGI:1925655, MGI:2141976
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 22
      Gene Ontology 11
      Phenotypes 65
    • Earliest
      J:135487 Bothwell MA, et al., Dissociation equilibrium constant of beta nerve growth factor. J Biol Chem. 1977 Dec 10;252(23):8532-6
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory