Ocm MGI Mouse Gene Detail - MGI:97401

Symbol

Ocm
Name

oncomodulin

Feature Type

protein coding gene
IDs

MGI:97401
NCBI Gene: 18261
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:143956622-143963488 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 82.85 cM, cytoband G1-3
Mapping Data

3 experiments

SNPs within 2kb

360 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97401	protein coding gene	Chr5:143956615-143987691 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030344	protein coding gene	Chr5:149330692-149338105 (-)
A/J	MGP_AJ_G0030313	protein coding gene	Chr5:142927154-142934701 (-)
AKR/J	MGP_AKRJ_G0030245	protein coding gene	Chr5:147377349-147385243 (-)
BALB/cJ	MGP_BALBcJ_G0030330	protein coding gene	Chr5:144157969-144164923 (-)
C3H/HeJ	MGP_C3HHeJ_G0030041	protein coding gene	Chr5:148219600-148226466 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030775	protein coding gene	Chr5:154794017-154801039 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027994	protein coding gene	Chr5:136712151-136718547 (-)
CAST/EiJ	MGP_CASTEiJ_G0029446	protein coding gene	Chr5:147738450-147745128 (-)
CBA/J	MGP_CBAJ_G0030011	protein coding gene	Chr5:161150506-161157342 (-)
DBA/2J	MGP_DBA2J_G0030161	protein coding gene	Chr5:142678136-142685002 (-)
FVB/NJ	MGP_FVBNJ_G0030116	protein coding gene	Chr5:141885065-141892346 (-)
LP/J	MGP_LPJ_G0030247	protein coding gene	Chr5:149939690-149947620 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030147	protein coding gene	Chr5:163530271-163537212 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030815	protein coding gene	Chr5:147262939-147269805 (-)
PWK/PhJ	MGP_PWKPhJ_G0029161	protein coding gene	Chr5:141779826-141786679 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028997	protein coding gene	Chr5:145002666-145012440 (-)
WSB/EiJ	MGP_WSBEiJ_G0029519	protein coding gene	Chr5:148071812-148078678 (-)

Human Ortholog

OCM, oncomodulin

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OCM, oncomodulin
Synonyms

OCM1, OM, ONCM
Links

HGNC:8105

NCBI Gene ID: 654231

neXtProt AC: NX_P0CE72

UniProt: P0CE72
Chr Location

chr7:5859718-5886363 (+) GRCh38

Human Ortholog

OCM2, oncomodulin 2
Synonyms

OCM, OM
Links

HGNC:34396

NCBI Gene ID: 4951

neXtProt AC: NX_P0CE71

UniProt: P0CE71
Chr Location

7q21.3; chr7:97984687-97991169 (-) GRCh38

MGI Vertebrate Homology

Ocm stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: OCM, OCM2
Gene Tree

Ocm

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Phenotype Summary

9 phenotypes from 2 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

9 strains or lines available

Mice homozygous for a knock-out allele exhibit deafness and degeneration of inner and outer cochlear hair cells and pillar cells.

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All GO Annotations

24
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

7
cDNA Data

3
Literature Summary

21

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ocm

ZFIN pvalb8, pvalb9

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All Sequences

47
RefSeq

10
UniProt

2
CCDS

CCDS51693.1

Ensembl

ENSMUSG00000029618 (Evidence)
NCBI Gene

18261

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029618	Ensembl Gene Model \| MGI Sequence Detail	6867	C57BL/6J	± kb
transcript	ENSMUST00000031622	Ensembl \| MGI Sequence Detail	658	Not Applicable
polypeptide	ENSMUSP00000031622	Ensembl \| MGI Sequence Detail	109	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR008080 Parvalbumin

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All nucleic 20

Genomic 9

cDNA 3

Primer pair 2

Other 6

Microarray probesets 2

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MGD-MRK-12973

Summaries

All 55

Developmental Gene Expression 21

Gene Ontology 3

Phenotypes 13
Earliest

J:16027 Banville D, et al., Retroviral long terminal repeat is the promoter of the gene encoding the tumor-associated calcium-binding protein oncomodulin in the rat. J Mol Biol. 1989 Jun 5;207(3):481-90
Latest

J:348705 Goodrich EJ, et al., Emx2 lineage tracing reveals antecedent patterns of planar polarity in the mouse inner ear. Development. 2024 May 15;151(10):dev202425

TSS for Ocm:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1744	Chr5:143963461-143963464 (-)	25 bp
Tssr54391	Chr5:143963414-143963425 (-)	68 bp
Tssr1743	Chr5:143963411-143963412 (-)	76 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24