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Odc1 Gene Detail
Summary
  • Symbol
    Odc1
  • Name
    ornithine decarboxylase, structural 1
  • Synonyms
    ODC
  • Feature Type
    protein coding gene
  • IDs
    MGI:97402
    NCBI Gene: 18263
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:17594906-17601503 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 8.11 cM
  • Mapping Data
    35 experiments
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97402
 protein coding gene Chr12:17594795-17601506 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019620
 protein coding gene Chr12:14995590-15005091 (+)
A/J MGP_AJ_G0019587
 protein coding gene Chr12:14458870-14467385 (+)
AKR/J MGP_AKRJ_G0019557
 protein coding gene Chr12:15129651-15138536 (+)
BALB/cJ MGP_BALBcJ_G0019563
 protein coding gene Chr12:14699342-14706238 (+)
C3H/HeJ MGP_C3HHeJ_G0019368
 protein coding gene Chr12:15045227-15054180 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020011
 protein coding gene Chr12:15501934-15510978 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017637
 protein coding gene Chr12:13941372-13948103 (+)
CAST/EiJ MGP_CASTEiJ_G0018923
 protein coding gene Chr12:14962482-14972598 (+)
CBA/J MGP_CBAJ_G0019339
 protein coding gene Chr12:16339989-16348535 (+)
DBA/2J MGP_DBA2J_G0019452
 protein coding gene Chr12:14366162-14399190 (+)
FVB/NJ MGP_FVBNJ_G0019443
 protein coding gene Chr12:14258712-14267823 (+)
LP/J MGP_LPJ_G0019523
 protein coding gene Chr12:15107725-15117337 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019478
 protein coding gene Chr12:16175595-16182718 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020050
 protein coding gene Chr12:14835079-14846035 (+)
PWK/PhJ MGP_PWKPhJ_G0018689
 protein coding gene Chr12:14415229-14421643 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0018974
 protein coding gene Chr12:14947586-14955723 (+)



Homology
more
  • Human Ortholog
    ODC1, ornithine decarboxylase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ODC1, ornithine decarboxylase 1
  • Synonyms
    BABS, NEDBA, NEDBIA, ODC
  • Links
    NCBI Gene ID: 4953
    neXtProt AC: NX_P11926
    UniProt: P11926

  • Chr Location
    2p25.1; chr2:10439968-10448327 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Odc1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos die prior to gastrulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1030
  • Tissues
    269
  • cDNA Data
    29
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18263 NCBI Gene Model | MGI Sequence Detail 6598 C57BL/6J ±  kb
    transcript NM_001409629 RefSeq | MGI Sequence Detail 2783 ZRU/MplStud  
    polypeptide P00860 UniProt | EBI | MGI Sequence Detail 461 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 6
      cDNA 30
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12979
    References
    more
    • Summaries
      All 168
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 10
      Phenotypes 45
    • Earliest
      J:7845 Janne OA, et al., Ornithine decarboxylase mRNA in mouse kidney: a low abundancy gene product regulated by androgens with rapid kinetics. Ann N Y Acad Sci. 1984;438:72-84
    • Latest
      J:348274 Bhalla M, et al., Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state. Mol Brain. 2024 Jan 12;17(1):3
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory