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Pbx3 Gene Detail
Summary
  • Symbol
    Pbx3
  • Name
    pre B cell leukemia homeobox 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97496
    NCBI Gene: 18516
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:34061469-34263154 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.84 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2858 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97496
 protein coding gene Chr2:34061469-34264168 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025637
 protein coding gene Chr2:32730987-32960286 (-)
A/J MGP_AJ_G0025614
 protein coding gene Chr2:31356495-31559570 (-)
AKR/J MGP_AKRJ_G0025584
 protein coding gene Chr2:32465937-32668327 (-)
BALB/cJ MGP_BALBcJ_G0025611
 protein coding gene Chr2:31461728-31665746 (-)
C3H/HeJ MGP_C3HHeJ_G0025371
 protein coding gene Chr2:32350800-32564879 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026055
 protein coding gene Chr2:33699451-33911814 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023464
 protein coding gene Chr2:30077262-30273512 (-)
CAST/EiJ MGP_CASTEiJ_G0024833
 protein coding gene Chr2:32326783-32543446 (-)
CBA/J MGP_CBAJ_G0025349
 protein coding gene Chr2:35007057-35243252 (-)
DBA/2J MGP_DBA2J_G0025482
 protein coding gene Chr2:31128673-31331970 (-)
FVB/NJ MGP_FVBNJ_G0025444
 protein coding gene Chr2:31013147-31220044 (-)
LP/J MGP_LPJ_G0025568
 protein coding gene Chr2:32649155-32864357 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025475
 protein coding gene Chr2:34539993-34762572 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026113
 protein coding gene Chr2:32340336-32560870 (-)
PWK/PhJ MGP_PWKPhJ_G0024581
 protein coding gene Chr2:31032731-31235583 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024381
 protein coding gene Chr2:32523864-32726003 (-)
WSB/EiJ MGP_WSBEiJ_G0024902
 protein coding gene Chr2:32520001-32734734 (-)



Homology
more
  • Human Ortholog
    PBX3, PBX homeobox 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PBX3, PBX homeobox 3
  • Links
    NCBI Gene ID: 5090
    neXtProt AC: NX_P40426
    UniProt: P40426

  • Chr Location
    9q33.3; chr9:125747345-125967377 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 5 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with hypoventilation and respiratory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1083
  • Tissues
    239
  • cDNA Data
    52
  • Literature Summary
    62
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038718 Ensembl Gene Model | MGI Sequence Detail 201686 C57BL/6J ±  kb
    transcript ENSMUST00000040638 Ensembl | MGI Sequence Detail 2587 Not Applicable  
    polypeptide ENSMUSP00000045281 Ensembl | MGI Sequence Detail 434 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 54
      Primer pair 5
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13165
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 62
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:2599 Monica K, et al., PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol. 1991 Dec;11(12):6149-57
    • Latest
      J:349843 Ning Y, et al., Transcription factor PBX4 regulates limb development and haematopoiesis in mice. Cell Prolif. 2024 May;57(5):e13580
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory