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Pcna Gene Detail
Summary
  • Symbol
    Pcna
  • Name
    proliferating cell nuclear antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:97503
    NCBI Gene: 18538
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:132091206-132095100 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 64.15 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97503
 protein coding gene Chr2:132091082-132095234 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026540
 protein coding gene Chr2:135820546-135824583 (-)
A/J MGP_AJ_G0026504
 protein coding gene Chr2:130294979-130299131 (-)
AKR/J MGP_AKRJ_G0026478
 protein coding gene Chr2:134051032-134056411 (-)
BALB/cJ MGP_BALBcJ_G0026516
 protein coding gene Chr2:130700002-130704154 (-)
C3H/HeJ MGP_C3HHeJ_G0026259
 protein coding gene Chr2:134499768-134503883 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026961
 protein coding gene Chr2:139946290-139953122 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024338
 protein coding gene Chr2:125011681-125015940 (-)
CAST/EiJ MGP_CASTEiJ_G0025720
 protein coding gene Chr2:134816557-134820673 (-)
CBA/J MGP_CBAJ_G0026239
 protein coding gene Chr2:145212618-145216655 (-)
DBA/2J MGP_DBA2J_G0026373
 protein coding gene Chr2:129692336-129696488 (-)
FVB/NJ MGP_FVBNJ_G0026337
 protein coding gene Chr2:128317855-128322007 (-)
LP/J MGP_LPJ_G0026477
 protein coding gene Chr2:136021404-136025519 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026357
 protein coding gene Chr2:148975978-148980093 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027016
 protein coding gene Chr2:134020364-134024956 (-)
PWK/PhJ MGP_PWKPhJ_G0025456
 protein coding gene Chr2:129275906-129280492 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025258
 protein coding gene Chr2:133168737-133172886 (-)
WSB/EiJ MGP_WSBEiJ_G0025794
 protein coding gene Chr2:134943391-134947543 (-)



Homology
more
  • Human Ortholog
    PCNA, proliferating cell nuclear antigen
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCNA, proliferating cell nuclear antigen
  • Synonyms
    ATLD2
  • Links
    NCBI Gene ID: 5111
    neXtProt AC: NX_P12004
    UniProt: P12004

  • Chr Location
    20p12.3; chr20:5114953-5126626 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PCNA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality before implantation due to defects in DNA replication. Mice homozygous for a knock-in allele show partial embryonic lethality during organogenesis, absent germ cells, infertility, and altered somatic hypermutation frequency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    91
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1771
  • Tissues
    419
  • cDNA Data
    302
  • Literature Summary
    713
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18538 NCBI Gene Model | MGI Sequence Detail 3895 C57BL/6J ±  kb
    transcript NM_011045 RefSeq | MGI Sequence Detail 1260 ZRU/MplStud  
    polypeptide P17918 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012421 proliferating cell nuclear antigen
      (term hierarchy)
    • InterPro Domains
      IPR046938 DNA clamp superfamily
      IPR000730 Proliferating cell nuclear antigen, PCNA
      IPR022659 Proliferating cell nuclear antigen, PCNA, conserved site
      IPR022649 Proliferating cell nuclear antigen, PCNA, C-terminal
      IPR022648 Proliferating cell nuclear antigen, PCNA, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 316
      Genomic 5
      cDNA 303
      Primer pair 7
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13178
    References
    more
    • Summaries
      All 837
      Developmental Gene Expression 713
      Gene Ontology 34
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:355461 Deng Z, et al., Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure. Heliyon. 2024 Sep 15;10(17):e37259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory