Cdk16 MGI Mouse Gene Detail - MGI:97516 - cyclin dependent kinase 16

Symbol

Cdk16
Name

cyclin dependent kinase 16
Synonyms

Crk5, Pctaire1, Pctk1

Feature Type

protein coding gene
IDs

MGI:97516
NCBI Gene: 18555
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

ChrX:20554210-20566119 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 16.18 cM
Mapping Data

3 experiments

SNPs within 2kb

220 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97516	protein coding gene	ChrX:20554193-20566119 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035595	protein coding gene	ChrX:15575360-15587286 (+)
A/J	MGP_AJ_G0035572	protein coding gene	ChrX:15666204-15678744 (+)
AKR/J	MGP_AKRJ_G0035505	protein coding gene	ChrX:16210362-16222288 (+)
BALB/cJ	MGP_BALBcJ_G0035565	protein coding gene	ChrX:15412217-15424143 (+)
C3H/HeJ	MGP_C3HHeJ_G0035283	protein coding gene	ChrX:15798134-15810060 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036101	protein coding gene	ChrX:15987163-15999927 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032965	protein coding gene	ChrX:13915952-13928061 (+)
CAST/EiJ	MGP_CASTEiJ_G0034574	protein coding gene	ChrX:15090246-15102148 (+)
CBA/J	MGP_CBAJ_G0035252	protein coding gene	ChrX:16722108-16734034 (+)
DBA/2J	MGP_DBA2J_G0035404	protein coding gene	ChrX:15468851-15480777 (+)
FVB/NJ	MGP_FVBNJ_G0035350	protein coding gene	ChrX:15369806-15381732 (+)
LP/J	MGP_LPJ_G0035486	protein coding gene	ChrX:15827327-15839265 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035394	protein coding gene	ChrX:16979093-16991019 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036108	protein coding gene	ChrX:15495246-15507172 (+)
PWK/PhJ	MGP_PWKPhJ_G0034275	protein coding gene	ChrX:14657020-14668985 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034115	protein coding gene	ChrX:15475785-15488834 (+)
WSB/EiJ	MGP_WSBEiJ_G0034709	protein coding gene	ChrX:15359468-15371398 (+)

Human Ortholog

CDK16, cyclin dependent kinase 16

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK16, cyclin dependent kinase 16
Synonyms

PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1
Links

HGNC:8749

NCBI Gene ID: 5127

neXtProt AC: NX_Q00536

UniProt: Q00536
Chr Location

Xp11.3; chrX:47217860-47229997 (+) GRCh38

MGI Vertebrate Homology

Cdk16 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK16
Gene Tree

Cdk16

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

6
Targeted

5
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility associated with asthenozoospermia and abnormal sperm morphology.

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All GO Annotations

42
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

779
Tissues

26
cDNA Data

21
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdk16

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All Sequences

90
RefSeq

8
UniProt

5
CCDS

CCDS30045.1, CCDS81103.1

Ensembl

ENSMUSG00000031065 (Evidence)
NCBI Gene

18555

			Length	Strain/Species	Flank
genomic	18555	NCBI Gene Model \| MGI Sequence Detail	11910	C57BL/6J	± kb
transcript	NM_001411707	RefSeq \| MGI Sequence Detail	3256	ZRU/MplStud
polypeptide	Q04735	UniProt \| EBI \| MGI Sequence Detail	496	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012441 cyclin-dependent kinase 16

(term hierarchy)
EC

2.7.11.22
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 24

cDNA 21

Primer pair 3

Microarray probesets 5

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MGD-MRK-13196, MGD-MRK-2149, MGI:88506

Summaries

All 53

Developmental Gene Expression 8

Gene Ontology 15

Phenotypes 10
Earliest

J:3108 Okuda T, et al., PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene. 1992 Nov;7(11):2249-58
Latest

J:325355 Rong Y, et al., USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation. Nucleic Acids Res. 2022 Jun 10;50(10):5599-5616

TSS for Cdk16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160667	ChrX:20554203-20554278 (+)	31 bp
Tssr160668	ChrX:20554618-20554720 (+)	459 bp
Tssr160669	ChrX:20554721-20554771 (+)	536 bp
Tssr160670	ChrX:20554797-20554809 (+)	593 bp
Tssr160671	ChrX:20559102-20559147 (+)	4,915 bp
Tssr160672	ChrX:20560366-20560385 (+)	6,166 bp
Tssr160673	ChrX:20561743-20561768 (+)	7,546 bp
Tssr160674	ChrX:20562784-20562797 (+)	8,581 bp
Tssr160675	ChrX:20564953-20564971 (+)	10,752 bp
Tssr160676	ChrX:20564982-20565017 (+)	10,790 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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