Cdk17 MGI Mouse Gene Detail - MGI:97517 - cyclin dependent kinase 17

Symbol

Cdk17
Name

cyclin dependent kinase 17
Synonyms

6430598J10Rik, MGC:25109, Pctk2

Feature Type

protein coding gene
IDs

MGI:97517
NCBI Gene: 237459
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:92996492-93086956 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 47.89 cM
Mapping Data

3 experiments

SNPs within 2kb

2614 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97517	protein coding gene	Chr10:92996492-93102933 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017648	protein coding gene	Chr10:94543554-94638244 (+)
A/J	MGP_AJ_G0017627	protein coding gene	Chr10:91270567-91352607 (+)
AKR/J	MGP_AKRJ_G0017585	protein coding gene	Chr10:93863361-93947106 (+)
BALB/cJ	MGP_BALBcJ_G0017590	protein coding gene	Chr10:91532879-91614537 (+)
C3H/HeJ	MGP_C3HHeJ_G0017413	protein coding gene	Chr10:93878372-93962167 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018047	protein coding gene	Chr10:97648533-97737039 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015729	protein coding gene	Chr10:86888612-86966448 (+)
CAST/EiJ	MGP_CASTEiJ_G0016979	protein coding gene	Chr10:93839506-93926964 (+)
CBA/J	MGP_CBAJ_G0017382	protein coding gene	Chr10:101708502-101804684 (+)
DBA/2J	MGP_DBA2J_G0017488	protein coding gene	Chr10:90366558-90447280 (+)
FVB/NJ	MGP_FVBNJ_G0017480	protein coding gene	Chr10:89579784-89657997 (+)
LP/J	MGP_LPJ_G0017562	protein coding gene	Chr10:95162620-95242541 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017511	protein coding gene	Chr10:103053904-103138690 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018084	protein coding gene	Chr10:93765477-93848689 (+)
PWK/PhJ	MGP_PWKPhJ_G0016759	protein coding gene	Chr10:90443030-90524485 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016547	protein coding gene	Chr10:92566668-92648164 (+)
WSB/EiJ	MGP_WSBEiJ_G0017037	protein coding gene	Chr10:93739382-93823381 (+)

Human Ortholog

CDK17, cyclin dependent kinase 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK17, cyclin dependent kinase 17
Synonyms

PCTAIRE2, PCTK2
Links

HGNC:8750

NCBI Gene ID: 5128

neXtProt AC: NX_Q00537

UniProt: Q00537
Chr Location

12q23.1; chr12:96278225-96400480 (-) GRCh38

MGI Vertebrate Homology

Cdk17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK17
Gene Tree

Cdk17

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

188
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

179
Targeted

4
Transposon induced

1
Genomic Mutations

2 involving Cdk17
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

64 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

32
cDNA Data

58
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDK17

Xenbase cdk17

less

All Sequences

82
RefSeq

20
UniProt

9
CCDS

CCDS48670.1

Ensembl

ENSMUSG00000020015 (Evidence)
NCBI Gene

237459

			Length	Strain/Species	Flank
genomic	237459	NCBI Gene Model \| MGI Sequence Detail	90465	C57BL/6J	± kb
transcript	NM_146239	RefSeq \| MGI Sequence Detail	3643	C57BL/6
polypeptide	Q8K0D0	UniProt \| EBI \| MGI Sequence Detail	523	Not Applicable

less

UniProt

9 Sequences
Protein Ontology

PR:000012442 cyclin-dependent kinase 17

(term hierarchy)
EC

2.7.11.22
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

less

All nucleic 60

cDNA 58

Primer pair 1

Other 1

Microarray probesets 1

less

MGD-MRK-13197, MGI:1923461

Summaries

All 49

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 22
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdk17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95247	Chr10:92996649-92996677 (+)	171 bp
Tssr95248	Chr10:92996686-92996756 (+)	229 bp
Tssr95249	Chr10:92996840-92996851 (+)	354 bp
Tssr95250	Chr10:92996953-92997009 (+)	489 bp
Tssr95252	Chr10:93020084-93020087 (+)	23,594 bp
Tssr95253	Chr10:93024041-93024076 (+)	27,567 bp
Tssr95254	Chr10:93045943-93045947 (+)	49,453 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24