Pd Gene Detail

Summary

• Symbol
  Pd
• Name
  pyrimidine degrading

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:97522
  NCBI Gene: 104167
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Mutations,
Alleles, and
Phenotypes

Strains C57BL/6J and BDP/J carry the low pyrimidine degrading enzyme activity allele; SJL/J and RF/J carry the high activity allele. Heterozygotes are intermediate. The locus likely affects enzyme structure, as the C57BL/6 enzyme is more thermolabile andhas lower substrate affinity than that of RF.

Sequences &
Gene Models

• NCBI Gene
  104167

Other
Accession IDs

MGD-MRK-13203

References

• Summaries
  All 3
• Earliest
  J:235 DAGG CP, et al., A GENE AFFECTING THE RATE OF PYRIMIDINE DEGRADATION IN MICE. Genetics. 1964 Jun;49:979-89
• Latest
  J:5178 Sanno Y, et al., Studies of a mutation affecting pyrimidine degradation in inbred mice. J Biol Chem. 1970 Nov 10;245(21):5668-76