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Cfp Gene Detail
Summary
  • Symbol
    Cfp
  • Name
    complement factor properdin
  • Synonyms
    Pfc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97545
    NCBI Gene: 18636
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:20791693-20797794 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 16.44 cM, cytoband A3
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97545
 protein coding gene ChrX:20791693-20797794 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035600
 protein coding gene ChrX:15828673-15834774 (-)
A/J MGP_AJ_G0035577
 protein coding gene ChrX:15908573-15914674 (-)
AKR/J MGP_AKRJ_G0035510
 protein coding gene ChrX:16461467-16467568 (-)
BALB/cJ MGP_BALBcJ_G0035570
 protein coding gene ChrX:15677469-15683570 (-)
C3H/HeJ MGP_C3HHeJ_G0035288
 protein coding gene ChrX:16046007-16052108 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036106
 protein coding gene ChrX:16247805-16253906 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032970
 protein coding gene ChrX:14164465-14170589 (-)
CAST/EiJ MGP_CASTEiJ_G0034579
 protein coding gene ChrX:15342936-15349049 (-)
CBA/J MGP_CBAJ_G0035257
 protein coding gene ChrX:16986458-16992559 (-)
DBA/2J MGP_DBA2J_G0035409
 protein coding gene ChrX:15711007-15717108 (-)
FVB/NJ MGP_FVBNJ_G0035355
 protein coding gene ChrX:15618816-15624917 (-)
LP/J MGP_LPJ_G0035491
 protein coding gene ChrX:16081661-16087762 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035399
 protein coding gene ChrX:17248468-17254569 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036113
 protein coding gene ChrX:15746116-15752217 (-)
PWK/PhJ MGP_PWKPhJ_G0034280
 protein coding gene ChrX:14911021-14917107 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034120
 protein coding gene ChrX:15755156-15761258 (-)
WSB/EiJ MGP_WSBEiJ_G0034714
 protein coding gene ChrX:15613185-15619282 (-)



Homology
more
  • Human Ortholog
    CFP, complement factor properdin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CFP, complement factor properdin
  • Synonyms
    BFD, PFC, PFD, PROPERDIN
  • Links
    NCBI Gene ID: 5199
    neXtProt AC: NX_P27918
    UniProt: P27918

  • Chr Location
    Xp11.23; chrX:47623172-47630305 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CFP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations have defects in the alternative complement pathway.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    3
  • cDNA Data
    47
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18636 NCBI Gene Model | MGI Sequence Detail 6102 C57BL/6J ±  kb
    transcript NM_008823 RefSeq | MGI Sequence Detail 1636 Not Specified  
    polypeptide P11680 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 47
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13243
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 34
    • Earliest
      J:7192 Farrar JJ, et al., Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2. J Immunol. 1983 Oct;131(4):1838-42
    • Latest
      J:335817 Wu Y, et al., HBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice via enhancing phagocytosis of tubular epithelial cells. Front Immunol. 2023;14:1183768
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory