Pgam1 MGI Mouse Gene Detail - MGI:97552 - phosphoglycerate mutase 1

Symbol

Pgam1
Name

phosphoglycerate mutase 1
Synonyms

2310050F24Rik, Pgam-1

Feature Type

protein coding gene
IDs

MGI:97552
NCBI Gene: 18648
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr19:41900362-41907099 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 35.44 cM
Mapping Data

2 experiments

SNPs within 2kb

215 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97552	protein coding gene	Chr19:41900310-41907104 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025130	protein coding gene	Chr19:41216044-41222004 (+)
A/J	MGP_AJ_G0025107	protein coding gene	Chr19:39232893-39239715 (+)
AKR/J	MGP_AKRJ_G0025075	protein coding gene	Chr19:40522542-40529157 (+)
BALB/cJ	MGP_BALBcJ_G0025101	protein coding gene	Chr19:39290162-39298609 (+)
C3H/HeJ	MGP_C3HHeJ_G0024861	protein coding gene	Chr19:40673402-40679358 (+)
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0022958	protein coding gene	Chr19:38588902-38595647 (+)
CAST/EiJ	MGP_CASTEiJ_G0024326	protein coding gene	Chr19:40342279-40350556 (+)
CBA/J	MGP_CBAJ_G0024841	protein coding gene	Chr19:44348787-44359706 (+)
DBA/2J	MGP_DBA2J_G0024973	protein coding gene	Chr19:39083212-39090184 (+)
FVB/NJ	MGP_FVBNJ_G0024934	protein coding gene	Chr19:38856421-38863891 (+)
LP/J	MGP_LPJ_G0025059	protein coding gene	Chr19:41207661-41214127 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024965	protein coding gene	Chr19:43975966-43984777 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025602	protein coding gene	Chr19:40560992-40566991 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0023879	protein coding gene	Chr19:39302270-39310131 (+)
WSB/EiJ	MGP_WSBEiJ_G0024396	protein coding gene	Chr19:40711504-40719023 (+)

Human Ortholog

PGAM1, phosphoglycerate mutase 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PGAM1, phosphoglycerate mutase 1
Synonyms

HEL-S-35, PGAMA, PGAM-B
Links

HGNC:8888

NCBI Gene ID: 5223

neXtProt AC: NX_P18669

UniProt: P18669
Chr Location

10q24.1; chr10:97426191-97433444 (+) GRCh38

Human Ortholog

PGAM4, phosphoglycerate mutase family member 4
Synonyms

dJ1000K24.1, PGAM1, PGAM3, PGAM-B
Links

HGNC:21731

NCBI Gene ID: 441531

neXtProt AC: NX_Q8N0Y7

UniProt: Q8N0Y7
Chr Location

Xq21.1; chrX:77967949-77969638 (-) GRCh38

MGI Vertebrate Homology

Pgam1 stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PGAM1, PGAM4
Protein SuperFamily

6PFK_2-Ptase
Gene Tree

Pgam1

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

4
Gene trapped

7
Targeted

5
Find Mice (IMSR)

25 strains or lines available

Knock-out of this gene results in embryonic lethality before E13.5. T cell-specific knock-out affects glycolysis, which causes a reduced T cell inflammatory response.

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All GO Annotations

17
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

877
Tissues

130
cDNA Data

596
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PGAM1

Xenbase pgam1

ZFIN pgam1a, pgam1b

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All Sequences

75
RefSeq

2
UniProt

3
CCDS

CCDS29815.1

Ensembl

ENSMUSG00000011752 (Evidence)
NCBI Gene

18648

			Length	Strain/Species	Flank
genomic	ENSMUSG00000011752	Ensembl Gene Model \| MGI Sequence Detail	6738	C57BL/6J	± kb
transcript	ENSMUST00000011896	Ensembl \| MGI Sequence Detail	1775	Not Applicable
polypeptide	ENSMUSP00000011896	Ensembl \| MGI Sequence Detail	254	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012592 phosphoglycerate mutase 1

(term hierarchy)
EC

5.4.2.11, 5.4.2.4
InterPro Domains

IPR029033 Histidine phosphatase superfamily

IPR013078 Histidine phosphatase superfamily, clade-1

IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site

IPR005952 Phosphoglycerate mutase 1
GlyGen

Q9DBJ1 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 600

cDNA 596

Primer pair 3

Other 1

Microarray probesets 4

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MGD-MRK-13253, MGD-MRK-13254, MGI:1915256

Summaries

All 54

Developmental Gene Expression 7

Gene Ontology 11

Phenotypes 11
Earliest

J:4443 Fundele R, et al., Enzyme patterns in trisomy 19 of the mouse. Dev Genet. 1981;2(3):291-303
Latest

J:335451 Okamoto M, et al., The Inhibition of Glycolysis in T Cells by a Jak Inhibitor Ameliorates the Pathogenesis of Allergic Contact Dermatitis in Mice. J Invest Dermatol. 2023 Apr 6;

TSS for Pgam1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156439	Chr19:41900136-41900144 (+)	-222 bp
Tssr156440	Chr19:41900290-41900313 (+)	-60 bp
Tssr156441	Chr19:41900314-41900334 (+)	-38 bp
Tssr156442	Chr19:41900335-41900347 (+)	-21 bp
Tssr156443	Chr19:41900359-41900373 (+)	4 bp
Tssr156444	Chr19:41900384-41900405 (+)	33 bp
Tssr156445	Chr19:41900450-41900475 (+)	101 bp
Tssr156446	Chr19:41905596-41905600 (+)	5,236 bp
Tssr156447	Chr19:41906212-41906244 (+)	5,866 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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