Pim2 MGI Mouse Gene Detail - MGI:97587 - proviral integration site 2

Symbol

Pim2
Name

proviral integration site 2
Synonyms

DXCch3, Pim-2

Feature Type

protein coding gene
IDs

MGI:97587
NCBI Gene: 18715
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

ChrX:7744545-7749671 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 3.55 cM
Mapping Data

4 experiments

SNPs within 2kb

108 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97587	protein coding gene	ChrX:7744501-7749671 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035527	protein coding gene	ChrX:2499128-2506104 (+)
A/J	MGP_AJ_G0035505	protein coding gene	ChrX:2461601-2467510 (+)
AKR/J	MGP_AKRJ_G0035437	protein coding gene	ChrX:2579016-2583869 (+)
BALB/cJ	MGP_BALBcJ_G0035501	protein coding gene	ChrX:2490239-2495410 (+)
C3H/HeJ	MGP_C3HHeJ_G0035209	protein coding gene	ChrX:2551698-2556867 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036025	protein coding gene	ChrX:2589317-2594486 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032901	protein coding gene	ChrX:2023031-2028128 (+)
CAST/EiJ	MGP_CASTEiJ_G0034510	protein coding gene	ChrX:2439372-2445982 (+)
CBA/J	MGP_CBAJ_G0035179	protein coding gene	ChrX:2707408-2712577 (+)
DBA/2J	MGP_DBA2J_G0035336	protein coding gene	ChrX:2486024-2491194 (+)
FVB/NJ	MGP_FVBNJ_G0035283	protein coding gene	ChrX:2445241-2450455 (+)
LP/J	MGP_LPJ_G0035414	protein coding gene	ChrX:2521035-2526297 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035323	protein coding gene	ChrX:2679117-2684285 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036043	protein coding gene	ChrX:2487509-2493326 (+)
PWK/PhJ	MGP_PWKPhJ_G0034211	protein coding gene	ChrX:2414908-2421191 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034049	protein coding gene	ChrX:2470385-2474878 (+)
WSB/EiJ	MGP_WSBEiJ_G0034633	protein coding gene	ChrX:2497345-2502509 (+)

Human Ortholog

PIM2, Pim-2 proto-oncogene, serine/threonine kinase

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIM2, Pim-2 proto-oncogene, serine/threonine kinase
Links

HGNC:8987

NCBI Gene ID: 11040

neXtProt AC: NX_Q9P1W9

UniProt: Q9P1W9
Chr Location

Xp11.23; chrX:48913182-48919024 (-) GRCh38

MGI Vertebrate Homology

Pim2 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: PIM2
Protein SuperFamily

STPK_Pim-1
Gene Tree

Pim2

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Targeted

6
Incidental Mutations

APF
Find Mice (IMSR)

7 strains or lines available

Homozygous null mice display reduced T cell proliferation in response to suboptimal alphaCD3 activation. Mice homozygous for a null allele exhibit reduced LPS-stimulated IL6 production from splenotcytes.

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All GO Annotations

53
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

35
cDNA Data

37
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN pim2

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All Sequences

36
RefSeq

2
UniProt

3
CCDS

CCDS29976.1

Ensembl

ENSMUSG00000031155 (Evidence)
NCBI Gene

18715

			Length	Strain/Species	Flank
genomic	18715	NCBI Gene Model \| MGI Sequence Detail	5127	C57BL/6J	± kb
transcript	NM_138606	RefSeq \| MGI Sequence Detail	2054	Not Specified
polypeptide	Q62070	UniProt \| EBI \| MGI Sequence Detail	370	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012733 serine/threonine-protein kinase Pim-2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR051138 PIM Serine/Threonine Kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR017348 Serine/threonine-protein kinase pim-1/2/3

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All nucleic 45

Genomic 5

cDNA 37

Primer pair 1

Other 2

Microarray probesets 4

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MGD-MRK-13309, MGD-MRK-13313, MGI:1891439

Summaries

All 67

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 25
Earliest

J:9795 Breuer ML, et al., Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas. EMBO J. 1989 Mar;8(3):743-8
Latest

J:330851 Lu C, et al., Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis. Cell Death Dis. 2022 Sep 15;13(9):790

TSS for Pim2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160459	ChrX:7744537-7744553 (+)	0 bp
Tssr160460	ChrX:7744945-7744956 (+)	406 bp
Tssr160461	ChrX:7744981-7744994 (+)	443 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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