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Prkcz Gene Detail
Summary
  • Symbol
    Prkcz
  • Name
    protein kinase C, zeta
  • Synonyms
    aPKCzeta, Pkcz, zetaPKC
  • Feature Type
    protein coding gene
  • IDs
    MGI:97602
    NCBI Gene: 18762
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155344586-155445818 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 86.17 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3222 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97602
 protein coding gene Chr4:155344579-155445856 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029211
 protein coding gene Chr4:159573554-159684242 (-)
A/J MGP_AJ_G0029176
 protein coding gene Chr4:152872087-152975273 (-)
AKR/J MGP_AKRJ_G0029124
 protein coding gene Chr4:157034825-157136062 (-)
BALB/cJ MGP_BALBcJ_G0029192
 protein coding gene Chr4:153342943-153448329 (-)
C3H/HeJ MGP_C3HHeJ_G0028913
 protein coding gene Chr4:157576217-157677432 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029641
 protein coding gene Chr4:165262015-165370046 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026887
 protein coding gene Chr4:145165504-145272772 (-)
CAST/EiJ MGP_CASTEiJ_G0028326
 protein coding gene Chr4:155009854-155116256 (-)
CBA/J MGP_CBAJ_G0028875
 protein coding gene Chr4:170228889-170340635 (-)
DBA/2J MGP_DBA2J_G0029024
 protein coding gene Chr4:152890496-152992709 (-)
FVB/NJ MGP_FVBNJ_G0028988
 protein coding gene Chr4:152130844-152236688 (-)
LP/J MGP_LPJ_G0029114
 protein coding gene Chr4:159494509-159605044 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029015
 protein coding gene Chr4:173080313-173189949 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029673
 protein coding gene Chr4:157637276-157746605 (-)
PWK/PhJ MGP_PWKPhJ_G0028046
 protein coding gene Chr4:149021380-149126312 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027880
 protein coding gene Chr4:151902577-152014720 (-)
WSB/EiJ MGP_WSBEiJ_G0028406
 protein coding gene Chr4:157809593-157918981 (-)



Homology
more
  • Human Ortholog
    PRKCZ, protein kinase C zeta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKCZ, protein kinase C zeta
  • Synonyms
    PKC2, PKC-ZETA
  • Links
    NCBI Gene ID: 5590
    neXtProt AC: NX_Q05513
    UniProt: Q05513

  • Chr Location
    1p36.33; chr1:2048504-2185395 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 7 genetic backgrounds
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Young, not mature, homozygous null mice have reduced B cell numbers and abnormal secondary lymph organ structure. Young mice have fewer Peyer's patches, poor delineation of B & T cell zones, and fewer follicles of small size. Spleens have less prominent B cell follicles and abnormal marginal zones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    129
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1136
  • Tissues
    276
  • cDNA Data
    63
  • Literature Summary
    150
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029053 Ensembl Gene Model | MGI Sequence Detail 101233 C57BL/6J ±  kb
    transcript ENSMUST00000030922 Ensembl | MGI Sequence Detail 2641 Not Applicable  
    polypeptide ENSMUSP00000030922 Ensembl | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      Genomic 1
      cDNA 63
      Primer pair 8
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-13334, MGI:2140186, MGI:2140684, MGI:2140714
    References
    more
    • Summaries
      All 297
      Developmental Gene Expression 150
      Gene Ontology 25
      Phenotypes 51
    • Earliest
      J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
    • Latest
      J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory