Serpinb2 MGI Mouse Gene Detail - MGI:97609 - serine (or cysteine) peptidase inhibitor, clade B, member 2

Symbol

Serpinb2
Name

serine (or cysteine) peptidase inhibitor, clade B, member 2
Synonyms

ovalbumin, PAI-2, Planh2

Feature Type

protein coding gene
IDs

MGI:97609
NCBI Gene: 18788
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:107439153-107453330 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 50.34 cM
Mapping Data

3 experiments

SNPs within 2kb

564 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97609	protein coding gene	Chr1:107439153-107463208 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016382	protein coding gene	Chr1:109760358-109787431 (+)
A/J	MGP_AJ_G0016363	protein coding gene	Chr1:105932328-105966208 (+)
AKR/J	MGP_AKRJ_G0016326	protein coding gene	Chr1:108849306-108878438 (+)
BALB/cJ	MGP_BALBcJ_G0016322	protein coding gene	Chr1:106035515-106062504 (+)
C3H/HeJ	MGP_C3HHeJ_G0016149	protein coding gene	Chr1:109266924-109295814 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016781	protein coding gene	Chr1:113919993-113946234 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014499	protein coding gene	Chr1:100049735-100073702 (+)
CAST/EiJ	MGP_CASTEiJ_G0015732	protein coding gene	Chr1:108197802-108226706 (+)
CBA/J	MGP_CBAJ_G0016121	protein coding gene	Chr1:117805411-117839558 (+)
DBA/2J	MGP_DBA2J_G0016228	protein coding gene	Chr1:104959467-104985857 (+)
FVB/NJ	MGP_FVBNJ_G0016227	protein coding gene	Chr1:103909200-103933135 (+)
LP/J	MGP_LPJ_G0016301	protein coding gene	Chr1:111037235-111063039 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016254	protein coding gene	Chr1:122241069-122267466 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016819	protein coding gene	Chr1:108840891-108868474 (+)
PWK/PhJ	MGP_PWKPhJ_G0015517	protein coding gene	Chr1:104002041-104026760 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015305	protein coding gene	Chr1:107504615-107529482 (+)
WSB/EiJ	MGP_WSBEiJ_G0015794	protein coding gene	Chr1:108740661-108768591 (+)

Human Ortholog

SERPINB2, serpin family B member 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINB2, serpin family B member 2
Synonyms

HsT1201, PAI, PAI-2, PAI2, PLANH2
Links

HGNC:8584

NCBI Gene ID: 5055

neXtProt AC: NX_P05120

UniProt: P05120
Chr Location

18q21.33-q22.1; chr18:63871692-63903888 (+) GRCh38

MGI Vertebrate Homology

Serpinb2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SERPINB2
Gene Tree

Serpinb2

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Phenotype Summary

13 phenotypes from 3 alleles in 2 genetic backgrounds
9 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Targeted

5
Genomic Mutations

3 involving Serpinb2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to a slight to mild reduction in platelet, lymphocyte, neutrophil, and monocyte cell number.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

794
Tissues

63
cDNA Data

17
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

4
UniProt

4
CCDS

CCDS15219.1

Ensembl

ENSMUSG00000062345 (Evidence)
NCBI Gene

18788

			Length	Strain/Species	Flank
genomic	18788	NCBI Gene Model \| MGI Sequence Detail	14178	C57BL/6J	± kb
transcript	NM_011111	RefSeq \| MGI Sequence Detail	2007	ZRU/MplStud
polypeptide	P12388	UniProt \| EBI \| MGI Sequence Detail	415	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000030198 plasminogen activator inhibitor 2

(term hierarchy)
InterPro Domains

IPR015556 Plasminogen activator inhibitor-2

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2
GlyGen

P12388 4 sites

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All nucleic 23

Genomic 2

cDNA 18

Primer pair 3

Microarray probesets 3

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MGD-MRK-13345

Summaries

All 74

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 28
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:352252 Piao YJ, et al., SerpinB2 deficiency is associated with delayed mammary tumor development and decreased pro-tumorigenic macrophage polarization. BMC Cancer. 2024 Jul 3;24(1):792

TSS for Serpinb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8334	Chr1:107439146-107439161 (+)	1 bp
Tssr8335	Chr1:107439163-107439187 (+)	22 bp
Tssr8336	Chr1:107439193-107439198 (+)	43 bp
Tssr8337	Chr1:107439219-107439232 (+)	73 bp
Tssr8338	Chr1:107439257-107439262 (+)	107 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24