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Plcd1 Gene Detail
Summary
  • Symbol
    Plcd1
  • Name
    phospholipase C, delta 1
  • Synonyms
    PLC-delta 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97614
    NCBI Gene: 18799
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:118900595-118922570 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.32 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    569 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97614
 protein coding gene Chr9:118900595-118922570 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035410
 protein coding gene Chr9:121785234-121806965 (-)
A/J MGP_AJ_G0035390
 protein coding gene Chr9:117288527-117310026 (-)
AKR/J MGP_AKRJ_G0035323
 protein coding gene Chr9:120324655-120346600 (-)
BALB/cJ MGP_BALBcJ_G0035386
 protein coding gene Chr9:117153787-117176013 (-)
C3H/HeJ MGP_C3HHeJ_G0035094
 protein coding gene Chr9:120793128-120815922 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035909
 protein coding gene Chr9:125132115-125153819 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032792
 protein coding gene Chr9:114481861-114503920 (-)
CAST/EiJ MGP_CASTEiJ_G0034398
 protein coding gene Chr9:120751584-120776793 (-)
CBA/J MGP_CBAJ_G0035061
 protein coding gene Chr9:129838299-129860230 (-)
DBA/2J MGP_DBA2J_G0035220
 protein coding gene Chr9:116724782-116746699 (-)
FVB/NJ MGP_FVBNJ_G0035167
 protein coding gene Chr9:115569133-115591065 (-)
LP/J MGP_LPJ_G0035299
 protein coding gene Chr9:122134738-122158199 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035208
 protein coding gene Chr9:130822181-130845650 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035928
 protein coding gene Chr9:120712587-120735672 (-)
PWK/PhJ MGP_PWKPhJ_G0034105
 protein coding gene Chr9:117136319-117158859 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033939
 protein coding gene Chr9:120814988-120847057 (-)
WSB/EiJ MGP_WSBEiJ_G0034519
 protein coding gene Chr9:120599538-120621327 (-)



Homology
more
  • Human Ortholog
    PLCD1, phospholipase C delta 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCD1, phospholipase C delta 1
  • Synonyms
    NDNC3, PLC-III
  • Links
    NCBI Gene ID: 5333
    neXtProt AC: NX_P51178
    UniProt: P51178

  • Chr Location
    3p22.2; chr3:38007496-38029642 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLCD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show reduced body size and various abnormalities of the skin and hair including alopecia, epidermal hyperplasia, enlarged sebaceous glands, various kinds of cysts, and skin tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1044
  • Tissues
    153
  • cDNA Data
    72
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18799 NCBI Gene Model | MGI Sequence Detail 21976 C57BL/6J ±  kb
    transcript NR_121571 RefSeq | MGI Sequence Detail 2715 C57BL/6  
    polypeptide Q8R3B1 UniProt | EBI | MGI Sequence Detail 756 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012832 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
      (term hierarchy)
    • EC
      3.1.4.11
    • InterPro Domains
      IPR028391 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, catalytic domain
      IPR046975 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, EF-hand domain
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR018247 EF-Hand 1, calcium-binding site
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR011993 PH-like domain superfamily
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
      IPR001849 Pleckstrin homology domain
    • GlyGen
      Q8R3B1 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 72
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13352, MGI:2143300, MGI:2143410
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 33
    • Earliest
      J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
    • Latest
      J:334969 Haan KD, et al., Osmotically evoked PLCdelta1-dependent translocation of DeltaN-TRPV1 channels in rat supraoptic neurons. iScience. 2023 Mar 17;26(3):106258
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory