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Plcg2 Gene Detail
Summary
  • Symbol
    Plcg2
  • Name
    phospholipase C, gamma 2
  • Synonyms
    MGC:38590, Plcg-2, PLCgamma2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97616
    NCBI Gene: 234779
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:118225030-118361881 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 64.26 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4639 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97616
 protein coding gene Chr8:118225014-118361881 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034174
 protein coding gene Chr8:120682131-120842264 (+)
A/J MGP_AJ_G0034154
 protein coding gene Chr8:115748554-115889087 (+)
AKR/J MGP_AKRJ_G0034081
 protein coding gene Chr8:119107371-119254326 (+)
BALB/cJ MGP_BALBcJ_G0034148
 protein coding gene Chr8:115948443-116089026 (+)
C3H/HeJ MGP_C3HHeJ_G0033859
 protein coding gene Chr8:119841486-119985851 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034668
 protein coding gene Chr8:124748021-124905492 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031610
 protein coding gene Chr8:108672020-108808278 (+)
CAST/EiJ MGP_CASTEiJ_G0033186
 protein coding gene Chr8:119712855-119870874 (+)
CBA/J MGP_CBAJ_G0033832
 protein coding gene Chr8:129268619-129442820 (+)
DBA/2J MGP_DBA2J_G0033988
 protein coding gene Chr8:114973301-115117200 (+)
FVB/NJ MGP_FVBNJ_G0033931
 protein coding gene Chr8:113982215-114129942 (+)
LP/J MGP_LPJ_G0034077
 protein coding gene Chr8:120815288-120970373 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033978
 protein coding gene Chr8:131851913-132007476 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034686
 protein coding gene Chr8:119212171-119368502 (+)
PWK/PhJ MGP_PWKPhJ_G0032888
 protein coding gene Chr8:114690843-114838728 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032728
 protein coding gene Chr8:117931173-118119755 (+)
WSB/EiJ MGP_WSBEiJ_G0033302
 protein coding gene Chr8:119929039-120080355 (+)



Homology
more
  • Human Ortholog
    PLCG2, phospholipase C gamma 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCG2, phospholipase C gamma 2
  • Synonyms
    APLAID, FCAS3, PLC-gamma-2, PLC-IV
  • Links
    NCBI Gene ID: 5336
    neXtProt AC: NX_P16885
    UniProt: P16885

  • Chr Location
    16q23.3; chr16:81779279-81962685 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLCG2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 12 alleles in 15 genetic backgrounds
    22 phenotypes from multigenic genotypes
    1 images
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for some null alleles show decreased B cell and impaired NK cell function. Other homozygous null alleles show aberrant separation of blood and lymphatic vessels. A point mutation associated with Alzheimer's disease protective effect leads to enhanced intracellular Ca2+ release in response to various stimuli in microglia and reduced phagocytosis and enhanced endocytosis in microglia and macrophages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    112
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1029
  • Tissues
    139
  • cDNA Data
    14
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034330 Ensembl Gene Model | MGI Sequence Detail 136852 C57BL/6J ±  kb
    transcript ENSMUST00000081232 Ensembl | MGI Sequence Detail 4298 Not Applicable  
    polypeptide ENSMUSP00000079991 Ensembl | MGI Sequence Detail 1265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 15
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13354, MGD-MRK-13356
    References
    more
    • Summaries
      All 160
      Developmental Gene Expression 12
      Gene Ontology 24
      Phenotypes 92
    • Earliest
      J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
    • Latest
      J:351573 Sasner M, et al., In vivo validation of late-onset Alzheimer's disease genetic risk factors. Alzheimers Dement. 2024 Jul;20(7):4970-4984
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory